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A prospective 5-year study on the use of transient elastography to monitor the improvement of non-alcoholic fatty liver disease following bariatric surgery
- Source :
- Scientific Reports, Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
- Publication Year :
- 2020
-
Abstract
- Liver stiffness measurement (LSM) by transient elastography (TE) is a non-invasive assessment for diagnosing and staging liver fibrosis in non-alcoholic fatty liver disease (NAFLD). Evidence on its role as a longitudinal monitoring tool is lacking. This study aims to evaluate the role of TE in monitoring NAFLD improvement following bariatric surgery. This study prospectively recruited 101 morbidly obese patients undergoing laparoscopic bariatric surgery for intraoperative liver biopsy. Thirty-seven patients of the cohort received perioperative TE. Postoperative anthropometric, biochemical and LSM data were collected annually for 5 years. In 101 patients receiving liver biopsy (mean age 40.0 ± 10.3 years, mean body-mass-index (BMI) 40.0 ± 5.7 kg/m2), NASH and liver fibrosis were diagnosed in 42 (41.6%) and 48 (47.5%) patients respectively. There were 29 (28.7%) stage 1, 11 (10.9%) stage 2, 7 (6.9%) stage 3, and 1 (1.0%) stage 4 fibrosis. In 37 patients receiving TE (mean age 38.9 ± 10.8 years, mean BMI 41.1 ± 5.6 kg/m2), the percentages of total weight loss were 21.1 ± 7.6% at 1 year, 19.7 ± 8.3% at 3 years, and 17.1 ± 7.0% at 5 years after surgery. The mean LSM reduced significantly from 9.8 ± 4.6 kPa at baseline to 6.9 ± 3.4 kPa at 1 year, 7.3 ± 3.0 kPa at 3 years, and 6.8 ± 2.6 kPa at 5 years (P = 0.002). Using pre-defined LSM cut-offs, the rates of significant fibrosis, advanced fibrosis and cirrhosis being ruled out at 5 years improved from baseline values of 43.7 to 87.5% (P P P
- Subjects :
- Adult
Male
medicine.medical_specialty
Cirrhosis
Science
Bariatric Surgery
030209 endocrinology & metabolism
Article
03 medical and health sciences
0302 clinical medicine
Fibrosis
Weight loss
Non-alcoholic Fatty Liver Disease
medicine
Humans
Longitudinal Studies
Postoperative Period
Prospective Studies
Obesity
Stage (cooking)
Liver diseases
Multidisciplinary
medicine.diagnostic_test
business.industry
Fatty liver
Perioperative
Middle Aged
medicine.disease
Surgery
Obesity, Morbid
Liver
Liver biopsy
Medicine
Elasticity Imaging Techniques
030211 gastroenterology & hepatology
Female
medicine.symptom
business
Transient elastography
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific reports
- Accession number :
- edsair.doi.dedup.....2a65ba9002085ad6fd8989277da222e0