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Setup for testing cameras for image guided surgery using a controlled NIR fluorescence mimicking light source and tissue phantom

Setup for testing cameras for image guided surgery using a controlled NIR fluorescence mimicking light source and tissue phantom

Authors :
Albert J. van der Veen
Rudolf M. Verdaasdonk
John H. Klaessens
Giota Georgiou
Physics and medical technology
Radiology and nuclear medicine
ACS - Microcirculation
Source :
Molecular-Guided Surgery: Molecules, Devices, and Applications III, 10049, Georgiou, G, Verdaasdonk, R M, Van Der Veen, A & Klaessens, J H 2017, Setup for testing cameras for image guided surgery using a controlled NIR fluorescence mimicking light source and tissue phantom . in Molecular-Guided Surgery : Molecules, Devices, and Applications III . vol. 10049, 100490E, SPIE, Molecular-Guided Surgery: Molecules, Devices, and Applications III, San Francisco, United States, 28/01/2017 . https://doi.org/10.1117/12.2253267
Publication Year :
2017
Publisher :
SPIE, 2017.

Abstract

In the development of new near-infrared (NIR) fluorescence dyes for image guided surgery, there is a need for new NIR sensitive camera systems that can easily be adjusted to specific wavelength ranges in contrast the present clinical systems that are only optimized for ICG. To test alternative camera systems, a setup was developed to mimic the fluorescence light in a tissue phantom to measure the sensitivity and resolution. Selected narrow band NIR LED's were used to illuminate a 6mm diameter circular diffuse plate to create uniform intensity controllable light spot (μW-mW) as target/source for NIR camera's. Layers of (artificial) tissue with controlled thickness could be placed on the spot to mimic a fluorescent 'cancer' embedded in tissue. This setup was used to compare a range of NIR sensitive consumer's cameras for potential use in image guided surgery. The image of the spot obtained with the cameras was captured and analyzed using ImageJ software. Enhanced CCD night vision cameras were the most sensitive capable of showing intensities < 1 μW through 5 mm of tissue. However, there was no control over the automatic gain and hence noise level. NIR sensitive DSLR cameras proved relative less sensitive but could be fully manually controlled as to gain (ISO 25600) and exposure time and are therefore preferred for a clinical setting in combination with Wi-Fi remote control. The NIR fluorescence testing setup proved to be useful for camera testing and can be used for development and quality control of new NIR fluorescence guided surgery equipment.

Details

Language :
English
Database :
OpenAIRE
Journal :
Molecular-Guided Surgery: Molecules, Devices, and Applications III, 10049, Georgiou, G, Verdaasdonk, R M, Van Der Veen, A & Klaessens, J H 2017, Setup for testing cameras for image guided surgery using a controlled NIR fluorescence mimicking light source and tissue phantom . in Molecular-Guided Surgery : Molecules, Devices, and Applications III . vol. 10049, 100490E, SPIE, Molecular-Guided Surgery: Molecules, Devices, and Applications III, San Francisco, United States, 28/01/2017 . https://doi.org/10.1117/12.2253267
Accession number :
edsair.doi.dedup.....2a6abf3b2e74ad00f51c1fccfea677c7
Full Text :
https://doi.org/10.1117/12.2253267