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Congenital hypothyroidism in a kitten resulting in decreased IGF-I concentration and abnormal liver function tests
- Source :
- Journal of Feline Medicine and Surgery. 12:487-490
- Publication Year :
- 2010
- Publisher :
- SAGE Publications, 2010.
-
Abstract
- A 7-month-old male kitten was presented with chronic constipation and retarded growth. Clinical examination revealed disproportional dwarfism with mild skeletal abnormalities and a palpable thyroid gland. The presumptive diagnosis of congenital hypothyroidism was confirmed by low serum total thyroxine (tT4) concentration prior to and after the administration of thyroid stimulation hormone (TSH), increased endogenous TSH concentration and abnormal thyroid scintigraphic scan. The kitten had abnormal liver function tests and decreased insulin-like growth factor 1 (IGF-1) concentration, both of which returned to normal in correspondence with an improvement of the clinical signs after 6 weeks of thyroxine therapy. Congenital hypothyroidism is a rare disease that may present with considerable variation in clinical manifestation. In cases in which clinical signs are ambiguous, disorders such as portosystemic shunt and hyposomatotropism have to be taken into account as differential diagnosis. As hypothyroidism may be associated with abnormal liver function tests and low IGF-1 concentrations, test results have to be interpreted carefully.
- Subjects :
- Male
endocrine system
medicine.medical_specialty
10253 Department of Small Animals
endocrine system diseases
FELINE
Thyrotropin
Dwarfism
Cat Diseases
Kitten
Diagnosis, Differential
Liver Function Tests
biology.animal
Internal medicine
Congenital Hypothyroidism
medicine
Animals
Insulin-Like Growth Factor I
610 Medicine & health
Small Animals
630 Agriculture
medicine.diagnostic_test
biology
TSH
business.industry
Thyroid
medicine.disease
IGF-I
Congenital hypothyroidism
Thyroxine
medicine.anatomical_structure
Endocrinology
HYPOTHYROIDISM
11404 Department of Clinical Diagnostics and Services
3404 Small Animals
Cats
570 Life sciences
590 Animals (Zoology)
Abnormal Liver Function Test
Liver function
BILE ACIDS
Portosystemic shunt
Liver function tests
business
Switzerland
Subjects
Details
- ISSN :
- 15322750 and 1098612X
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Journal of Feline Medicine and Surgery
- Accession number :
- edsair.doi.dedup.....2a6c43edda3460ec978e389265e85231