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BIOCHEMICAL ALTERATIONS OF THE TUNICA ALBUGINEA IN IMPOTENCE
- Source :
- Journal of Urology. 158:1778-1782
- Publication Year :
- 1997
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 1997.
-
Abstract
- The objectives of this study were to quantify the immunohistochemical stainings of collagen types I, III and IV, and investigate the value of glycohistochemical staining with 3 lectin types specific to a particular glycan structure, Arachis hypogaea, Triticum vulgare and concanavalin A, as a method of defining possible changes in the collagen structure of the tunica albuginea in potent and impotent patients.The study involved 4 normal men, 4 with pure venous leakage and 4 with pure arterial disease. Collagen types I, III and IV, and lectins Arachis hypogaea, Triticum vulgare and concanavalin A were studied using a cell image processor. The labeling index relates to the percentage of staining and mean optical density relates to the staining intensity.Mean labeling index values for the 3 types of collagen and lectins were similar (p0.05). Mean optical density value relating to collagen type I was significantly higher in the arteriogenic group than in the other groups (p0.05), while mean optical density value of collagen type IV was significantly higher in the venogenic group than in the 2 other groups (p0.05). Mean optical density values relating to the 3 lectin types were similar in the 3 clinical groups (p0.05).An alteration in the distribution and structure of the various collagen types and lectins in the tunica albuginea of impotent patients has been shown that may interfere with normal function and lead to impotence.
Details
- ISSN :
- 15273792 and 00225347
- Volume :
- 158
- Database :
- OpenAIRE
- Journal :
- Journal of Urology
- Accession number :
- edsair.doi.dedup.....2ab8194acdad099ca97d6f156b939e81