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TRPV1 modulation of contextual fear memory depends on stimulus intensity and endocannabinoid signalling in the dorsal hippocampus

Authors :
Lia P. Iglesias
Heliana B. Fernandes
Aline S. de Miranda
Malena M. Perez
Lucia H. Faccioli
Carlos A. Sorgi
Leandro J. Bertoglio
Daniele C. Aguiar
Carsten T. Wotjak
Fabrício A. Moreira
Source :
Neuropharmacology. 224
Publication Year :
2022

Abstract

The transient receptor potential vanilloid type-1 (TRPV1) channels have been implicated in the modulation of aversive responses. The endocannabinoid anandamide acts as an endogenous TRPV1 agonist, exerting opposite functions at TRPV1 and type-1 cannabinoid receptors (CB

Details

ISSN :
18737064
Volume :
224
Database :
OpenAIRE
Journal :
Neuropharmacology
Accession number :
edsair.doi.dedup.....2abdb7909232aff077f3060c6efcb1a4