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Presence of White Matter Lesions Associated with Diabetes-Associated Cognitive Decline in Male Rat Models of Pre-Type 2 Diabetes
- Source :
- Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
- Publication Year :
- 2019
- Publisher :
- International Scientific Information, Inc., 2019.
-
Abstract
- BACKGROUND The aim of this study was to determine the association between white matter lesions (WML) and diabetes-associated cognitive decline (DACD) in rat models of type 2 diabetes (T2DM). MATERIAL AND METHODS Sixty Sprague-Dawley male rats were divided into 4 groups: control, control+metformin, T2DM, and T2DM+metformin groups. The T2DM groups were fed a diet high in fat and glucose to induce impaired glucose tolerance (IGT) and then were injected with streptozotocin to induce T2DM. The Morris water maze test was used to evaluate cognitive function. Brain diffusion tensor imaging scans were performed for WML. The expression of myelin basic protein (MBP), oligodendrocyte transcription factor 1 (OLIG1), and OLIG2 (markers of brain damage and repair) was determined using immunofluorescence. After IGT, the fractional anisotropy (FA) values of the right thalamus area were significantly lower in both T2DM groups compared with controls. RESULTS Eight weeks after streptozotocin injection, the FA values of the thalamus were lower in the T2DM (bilateral thalamus) group and T2DM+metformin (left thalamus) group than in controls, while the FA values in the left thalamus area were lower in the T2DM+metformin group than in the control and control+metformin groups. The maze escape latency was longer and the number of rats passing through the platform was smaller in the T2DM and T2DM+metformin groups than in the control group. MBP levels were lower and OLIG1 and OLIG2 levels were higher in both T2DM groups than in controls. CONCLUSIONS WML is associated with DACD and appears before the onset of T2DM and signs of DACD and plays a role in diabetes-associated cognitive decline. Metformin reduces WMLs but does not rescue cognitive dysfunction.
- Subjects :
- Male
medicine.medical_specialty
endocrine system diseases
Morris water navigation task
Nerve Tissue Proteins
Type 2 diabetes
030204 cardiovascular system & hematology
Diabetes Mellitus, Experimental
Prediabetic State
Rats, Sprague-Dawley
Impaired glucose tolerance
03 medical and health sciences
0302 clinical medicine
Thalamus
Diabetes mellitus
Internal medicine
medicine
Animals
Cognitive Dysfunction
Cognitive decline
Maze Learning
Swimming
business.industry
Animal Study
nutritional and metabolic diseases
General Medicine
medicine.disease
Streptozotocin
White Matter
Hyperintensity
Metformin
Disease Models, Animal
Oligodendroglia
Diffusion Tensor Imaging
Endocrinology
Diabetes Mellitus, Type 2
030220 oncology & carcinogenesis
Anisotropy
business
Demyelinating Diseases
medicine.drug
Subjects
Details
- ISSN :
- 16433750
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Medical Science Monitor
- Accession number :
- edsair.doi.dedup.....2abedbab1987bbb33e322af050237991