Back to Search
Start Over
In vitro reconstitution of pancreatic islets
- Source :
- Organogenesis. 10:225-230
- Publication Year :
- 2014
- Publisher :
- Informa UK Limited, 2014.
-
Abstract
- The lack of transplantable pancreatic islets is a serious problem that affects the treatment of patients with type 1 diabetes mellitus. Beta cells can be induced from various sources of stem or progenitor cells, including induced pluripotent stem cells in the near future; however, the reconstitution of islets from β cells in culture dishes is challenging. The generation of highly functional islets may require three-dimensional spherical cultures that resemble intact islets. This review discusses recent advances in the reconstitution of islets. Several factors affect the reconstitution of pseudoislets with higher functions, such as architectural similarity, cell-to-cell contact, and the production method. The actual transplantation of naked or encapsulated pseudoislets and islet-like cell clusters from various stem cell sources is also discussed. Advancing our understanding of the methods used to reconstitute pseudoislets should expand the range of potential strategies available for developing de novo islets for therapeutic applications.
- Subjects :
- endocrine system
Embryology
Cell signaling
endocrine system diseases
Islets of Langerhans Transplantation
Biomedical Engineering
Review
Cell Communication
Islets of Langerhans
Tissue engineering
Animals
Humans
Regeneration
Medicine
Progenitor cell
Induced pluripotent stem cell
Transplantation
business.industry
Stem Cells
Pancreatic islets
Regeneration (biology)
Cell biology
medicine.anatomical_structure
Immunology
Artificial Organs
Stem cell
business
Developmental Biology
Subjects
Details
- ISSN :
- 15558592 and 15476278
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Organogenesis
- Accession number :
- edsair.doi.dedup.....2ac33ab0002aecb80bcd89fabac6650d