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The genetic architecture of the human cerebral cortex
- Source :
- Science / Science now Science now 367(6484), 1340 (2020). doi:10.1126/science.aay6690, SCIENCE, Science, 367(6484):aay6690. AMER ASSOC ADVANCEMENT SCIENCE, Science, Digital.CSIC. Repositorio Institucional del CSIC, instname, Science, 367(6484):eaay6690, 1-14. American Association for the Advancement of Science, Science, 367(6484):6690, 1340-+. American Association for the Advancement of Science, Grasby, K L, Armstrong, N J, Brouwer, R M, den Braber, A, Fedko, I O, Ford, J M, Heslenfeld, D J, Hottenga, J-J, Jansen, I E, Milaneschi, Y, Davies, G E, Boomsma, D I, de Geus, E J C, Oosterlaan, J, Penninx, B W J H, Polderman, T J C, Posthuma, D, van 't Ent, D, Medland, S E & Alzheimer’s Disease Neuroimaging Initiative 2020, ' The genetic architecture of the human cerebral cortex ', Science, vol. 367, no. 6484, eaay6690, pp. 1-14 . https://doi.org/10.1126/science.aay6690, Science, 367(6484), 1340-+. AMER ASSOC ADVANCEMENT SCIENCE, Science, 367(6484):aay6690. American Association for the Advancement of Science, Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)-Genetics working group 2020, ' The genetic architecture of the human cerebral cortex ', Science, vol. 367, no. 6484, aay6690 . https://doi.org/10.1126/science.aay6690, Science / Science now 367(6484), eaay6690-(2020). doi:10.1126/science.aay6690, Lancaster, T M 2020, ' The genetic architecture of the human cerebral cortex ', Science, vol. 367, no. 6484, eaay6990 . https://doi.org/10.1126/science.aay6690, Science, 367, 1-15, Science, 367, 6484, pp. 1-15, eaay6690, Science, 2020, 367 (6484), pp.eaay6690. ⟨10.1126/science.aay6690⟩, Science, Vol. 367, No. 6484, Science, American Association for the Advancement of Science, 2020, 367 (6484), pp.eaay6690. ⟨10.1126/science.aay6690⟩, Grasby, K L, Jahanshad, N, Painter, J N, Colodro-conde, L, Bralten, J, Hibar, D P, Lind, P A, Pizzagalli, F, Ching, C R K, Mcmahon, M A B, Shatokhina, N, Zsembik, L C P, Thomopoulos, S I, Zhu, A H, Strike, L T, Agartz, I, Alhusaini, S, Almeida, M A A, Alnæs, D, Amlien, I K, Andersson, M, Ard, T, Armstrong, N J, Ashley-koch, A, Atkins, J R, Bernard, M, Brouwer, R M, Buimer, E E L, Bülow, R, Bürger, C, Cannon, D M, Chakravarty, M, Chen, Q, Cheung, J W, Couvy-duchesne, B, Dale, A M, Dalvie, S, De Araujo, T K, De Zubicaray, G I, De Zwarte, S M C, Den Braber, A, Doan, N T, Dohm, K, Ehrlich, S, Harris, M A, Luciano, M, Wardlaw, J M, Doherty, C P & Bastin, M E & Deary, I J 2020, ' The genetic architecture of the human cerebral cortex ', Science, vol. 367, no. 6484, eaay6690 . https://doi.org/10.1126/science.aay6690, Grasby, K L, Jahanshad, N, Painter, J N, Colodro-Conde, L, Bralten, J, Hibar, D P, Lind, P A, Pizzagalli, F, Ching, C R K, McMahon, M A B, Shatokhina, N, Zsembik, L C P, Thomopoulos, S I, Zhu, A H, Strike, L T, Agartz, I, Alhusaini, S, Almeida, M A A, Alnæs, D, Amlien, I K, Andersson, M, Ard, T, Armstrong, N J, Ashley-Koch, A, Atkins, J R, Bernard, M, Brouwer, R M, Buimer, E E L, Bülow, R, Bürger, C, Cannon, D M, Chakravarty, M, Chen, Q, Cheung, J W, Couvy-Duchesne, B, Dale, A M, Dalvie, S, de Araujo, T K, de Zubicaray, G I, de Zwarte, S M C, den Braber, A, Doan, N T, Dohm, K, Jia, T, Tansey, K E, Walton, E, Zhang, Z, Quinlan, E B & Desrivières, S & Schumann, G 2020, ' The genetic architecture of the human cerebral cortex ', Science, vol. 367, no. 6484, aay6690 . https://doi.org/10.1126/science.aay6690
- Publication Year :
- 2020
- Publisher :
- Assoc.73085, 2020.
-
Abstract
- Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)—Genetics working group.<br />The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder.
- Subjects :
- 0301 basic medicine
Netherlands Twin Register (NTR)
[SDV]Life Sciences [q-bio]
LOCI
Genome-wide association study
Brain mapping
0302 clinical medicine
Cognition
Cortex (anatomy)
ComputingMilieux_MISCELLANEOUS
Cerebral Cortex
0303 health sciences
Brain Mapping
Multidisciplinary
COMMON VARIANTS
Parkinson Disease
Organ Size
Central sulcus
Magnetic Resonance Imaging
medicine.anatomical_structure
Cerebral cortex
Neuroinformatics
EXPRESSION
endocrine system
central sulcus
SURFACE-AREA
Biology
Article
03 medical and health sciences
SDG 3 - Good Health and Well-being
Genetic variation
medicine
Attention deficit hyperactivity disorder
Humans
General
Gene
METAANALYSIS
030304 developmental biology
Progenitor
CORTICAL SULCI
Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7]
Genetic variants
Genetic Variation
Attention Deficit Disorder with Hyperactivity
Genetic Loci
Genome-Wide Association Study
functional annotation
medicine.disease
Genetic architecture
030104 developmental biology
Evolutionary biology
OBSERVER-INDEPENDENT CHARACTERIZATION
Multiple comparisons problem
ddc:320
genome-wide association
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 00368075 and 10959203
- Database :
- OpenAIRE
- Journal :
- Science / Science now Science now 367(6484), 1340 (2020). doi:10.1126/science.aay6690, SCIENCE, Science, 367(6484):aay6690. AMER ASSOC ADVANCEMENT SCIENCE, Science, Digital.CSIC. Repositorio Institucional del CSIC, instname, Science, 367(6484):eaay6690, 1-14. American Association for the Advancement of Science, Science, 367(6484):6690, 1340-+. American Association for the Advancement of Science, Grasby, K L, Armstrong, N J, Brouwer, R M, den Braber, A, Fedko, I O, Ford, J M, Heslenfeld, D J, Hottenga, J-J, Jansen, I E, Milaneschi, Y, Davies, G E, Boomsma, D I, de Geus, E J C, Oosterlaan, J, Penninx, B W J H, Polderman, T J C, Posthuma, D, van 't Ent, D, Medland, S E & Alzheimer’s Disease Neuroimaging Initiative 2020, ' The genetic architecture of the human cerebral cortex ', Science, vol. 367, no. 6484, eaay6690, pp. 1-14 . https://doi.org/10.1126/science.aay6690, Science, 367(6484), 1340-+. AMER ASSOC ADVANCEMENT SCIENCE, Science, 367(6484):aay6690. American Association for the Advancement of Science, Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)-Genetics working group 2020, ' The genetic architecture of the human cerebral cortex ', Science, vol. 367, no. 6484, aay6690 . https://doi.org/10.1126/science.aay6690, Science / Science now 367(6484), eaay6690-(2020). doi:10.1126/science.aay6690, Lancaster, T M 2020, ' The genetic architecture of the human cerebral cortex ', Science, vol. 367, no. 6484, eaay6990 . https://doi.org/10.1126/science.aay6690, Science, 367, 1-15, Science, 367, 6484, pp. 1-15, eaay6690, Science, 2020, 367 (6484), pp.eaay6690. ⟨10.1126/science.aay6690⟩, Science, Vol. 367, No. 6484, Science, American Association for the Advancement of Science, 2020, 367 (6484), pp.eaay6690. ⟨10.1126/science.aay6690⟩, Grasby, K L, Jahanshad, N, Painter, J N, Colodro-conde, L, Bralten, J, Hibar, D P, Lind, P A, Pizzagalli, F, Ching, C R K, Mcmahon, M A B, Shatokhina, N, Zsembik, L C P, Thomopoulos, S I, Zhu, A H, Strike, L T, Agartz, I, Alhusaini, S, Almeida, M A A, Alnæs, D, Amlien, I K, Andersson, M, Ard, T, Armstrong, N J, Ashley-koch, A, Atkins, J R, Bernard, M, Brouwer, R M, Buimer, E E L, Bülow, R, Bürger, C, Cannon, D M, Chakravarty, M, Chen, Q, Cheung, J W, Couvy-duchesne, B, Dale, A M, Dalvie, S, De Araujo, T K, De Zubicaray, G I, De Zwarte, S M C, Den Braber, A, Doan, N T, Dohm, K, Ehrlich, S, Harris, M A, Luciano, M, Wardlaw, J M, Doherty, C P & Bastin, M E & Deary, I J 2020, ' The genetic architecture of the human cerebral cortex ', Science, vol. 367, no. 6484, eaay6690 . https://doi.org/10.1126/science.aay6690, Grasby, K L, Jahanshad, N, Painter, J N, Colodro-Conde, L, Bralten, J, Hibar, D P, Lind, P A, Pizzagalli, F, Ching, C R K, McMahon, M A B, Shatokhina, N, Zsembik, L C P, Thomopoulos, S I, Zhu, A H, Strike, L T, Agartz, I, Alhusaini, S, Almeida, M A A, Alnæs, D, Amlien, I K, Andersson, M, Ard, T, Armstrong, N J, Ashley-Koch, A, Atkins, J R, Bernard, M, Brouwer, R M, Buimer, E E L, Bülow, R, Bürger, C, Cannon, D M, Chakravarty, M, Chen, Q, Cheung, J W, Couvy-Duchesne, B, Dale, A M, Dalvie, S, de Araujo, T K, de Zubicaray, G I, de Zwarte, S M C, den Braber, A, Doan, N T, Dohm, K, Jia, T, Tansey, K E, Walton, E, Zhang, Z, Quinlan, E B & Desrivières, S & Schumann, G 2020, ' The genetic architecture of the human cerebral cortex ', Science, vol. 367, no. 6484, aay6690 . https://doi.org/10.1126/science.aay6690
- Accession number :
- edsair.doi.dedup.....2ad09770d15de97917d5e22cb9f4e679
- Full Text :
- https://doi.org/10.1126/science.aay6690