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Diagnostic accuracy of metronome-paced tachypnea to detect dynamic hyperinflation
- Source :
- Clinical Physiology and Functional Imaging, 33, 62-9, Clinical Physiology and Functional Imaging, 33, 1, pp. 62-9
- Publication Year :
- 2013
-
Abstract
- Item does not contain fulltext INTRODUCTION: This prospective study was carried out to investigate if metronome-paced tachypnea (MPT) can serve as an accurate diagnostic tool to identify patients with chronic obstructive pulmonary disease (COPD) who are susceptible to develop dynamic hyperinflation during exercise. Commonly, this is assessed by measuring change in inspiratory capacity (IC) during cardiopulmonary exercise testing (CPET), which, however, is complex and laborious. METHODS: Fifty-three patients with COPD (FEV(1) 58 +/- 22%pred) and 20 age-matched healthy subjects were characterized by lung function testing and performed CPET (reference standard) and MPT. The repeatability coefficient of IC (10.2%) was used as cut-off to classify subjects as hyperinflators during CPET. Subsequently, dynamic hyperinflation was measured after MPT. With receiver operating characteristic analysis, the optimal cut-off for MPT-induced dynamic hyperinflation was determined and sensitivity and specificity of MPT to identify hyperinflators were evaluated. RESULTS: With 10.2% decrease in IC as cut-off for CPET-induced dynamic hyperinflation, the optimal cut-off for MPT was 11.1% decrease in IC. Using these cut-offs, MPT had a sensitivity of 85% and specificity of 85% to identify the subjects who hyperinflated during CPET. CONCLUSIONS: The MPT test shows good overall accuracy to identify subjects who are susceptible to develop dynamic hyperinflation during CPET. Before considering the use of MPT as a screening tool for dynamic hyperinflation in COPD, sensitivity and specificity need further evaluation.
- Subjects :
- Male
Periodicity
Time Factors
Physiology
Vital Capacity
law.invention
Inspiratory Capacity
Pulmonary Disease, Chronic Obstructive
law
Forced Expiratory Volume
Prospective Studies
Dynamic hyperinflation
Lung
Observer Variation
Tachypnea
COPD
medicine.diagnostic_test
General Medicine
Middle Aged
Pathogenesis and modulation of inflammation [N4i 1]
Predictive value of tests
Cardiology
Female
medicine.symptom
Poverty-related infectious diseases Aetiology, screening and detection [N4i 3]
Spirometry
medicine.medical_specialty
Respiratory physiology
Metronome
Sensitivity and Specificity
Predictive Value of Tests
Physiology (medical)
Internal medicine
medicine
Humans
Aged
Analysis of Variance
business.industry
Poverty-related infectious diseases [N4i 3]
Reproducibility of Results
medicine.disease
ROC Curve
Case-Control Studies
Physical therapy
Exercise Test
Respiratory Mechanics
business
Subjects
Details
- ISSN :
- 14750961
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Clinical Physiology and Functional Imaging
- Accession number :
- edsair.doi.dedup.....2ae3fface6438fa4a6fac70a41630417