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Pyrazole NNRTIs 1: design and initial optimisation of a novel template
- Source :
- Bioorganicmedicinal chemistry letters. 19(19)
- Publication Year :
- 2009
-
Abstract
- The design and synthesis of a novel series of non-nucleoside HIV reverse transcriptase inhibitors (NNRTIs) based on a pyrazole template is described. These compounds are active against wild type reverse transcriptase (RT) and retain activity against clinically important mutants.
- Subjects :
- Molecular model
Stereochemistry
Anti-HIV Agents
Clinical Biochemistry
Pharmaceutical Science
Pyrazole
Biochemistry
Chemical synthesis
chemistry.chemical_compound
Structure-Activity Relationship
Drug Discovery
medicine
Humans
Molecular Biology
Reverse-transcriptase inhibitor
RNA-Directed DNA Polymerase
Organic Chemistry
Wild type
virus diseases
Nucleotidyltransferase
Reverse transcriptase
HIV Reverse Transcriptase
chemistry
Drug Design
Microsomes, Liver
Molecular Medicine
Pyrazoles
Reverse Transcriptase Inhibitors
medicine.drug
Subjects
Details
- ISSN :
- 14643405
- Volume :
- 19
- Issue :
- 19
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry letters
- Accession number :
- edsair.doi.dedup.....2ae5c45485d496c3861bcd3d4f846411