Health-related quality of life in high-grade glioma patients: a prospective single-center study

In this single center study, we aimed to assess quality of life and cognitive and emotional distress in patients treated for high-grade glioma. A hundred and eighteen patients with high-grade glioma were prospectively enrolled. We assessed HRQoL at baseline (after surgery before radiotherapy), at the end of radiotherapy and during follow-up (every 3 months for the first 2 years and every 6 months between 2 and 5 years) using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire 30 (EORTC-C30), Brain Cancer Module-20 (BN-20), Minimental State Examination (MMSE) and Hospital Anxiety and Depression Scale (HADS). Baseline scores, and first 18-month follow-up period scores were included to statistical analysis. Sixty-five (55%) patients had progressive tumor. Global score, physical, role and emotional function, insomnia (p for each