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Radical Prostatectomy for Localized Prostate Cancer in Renal Transplant Recipients: 13 Cases Studied at a Single Center
- Source :
- Transplantation Proceedings. 50:2539-2544
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Objectives We aimed to evaluate the feasibility and efficacy of surgical prostatectomy in renal transplant recipients (RTRs). Methods Between January 2008 and February 2017, we identified 13 RTRs who were diagnosed with localized prostate cancer and underwent radical prostatectomy. We reviewed all available clinicopathologic data for these 13 patients. Results The median patient age was 61 years and median serum prostate-specific antigen (PSA) was 8.79 ng/mL. The mean period between transplantation and diagnosis of prostate cancer was 136 months. The sources for the kidney transplants included 10 living and 3 deceased donors. Biopsies indicated that the Gleason scores were 7 in 10 patients and 8 to 10 in 3 patients. Meanwhile, the D'Amico risk classification indicated an intermediate risk in 9 patients and a high risk in 4 patients. Eight patients were at stage cT1 and 5 were at stage cT2. The surgical procedure was retropubic radical prostatectomy in one recipient, laparoscopic radical prostatectomy in 3 recipients, and robot-assisted radical prostatectomy in 9 RTRs. Intraoperative complications were not noted in any patient, although one patient demonstrated postoperative complications (Clavien grade ≥ 3). An indwelling urinary catheter was required in 3 patients for over 3 weeks due to delayed wound healing. Biochemical recurrence evaluated by PSA monitoring occurred in four patients. Postoperative graft function was stable in all but one patient who required resumption of dialysis before prostatectomy; however, all patients are alive at the time of publication with 12 patients showing well-functioning renal allografts. Conclusion Prostatectomy may be a feasible and effective technique as an initial treatment for RTRs with localized prostate cancer.
- Subjects :
- Male
Biochemical recurrence
medicine.medical_specialty
Laparoscopic radical prostatectomy
medicine.medical_treatment
030232 urology & nephrology
Urology
030230 surgery
Single Center
03 medical and health sciences
Prostate cancer
0302 clinical medicine
medicine
Humans
Stage (cooking)
Dialysis
Aged
Retrospective Studies
Prostatectomy
Transplantation
business.industry
Prostatic Neoplasms
Middle Aged
Prostate-Specific Antigen
medicine.disease
Kidney Transplantation
Transplant Recipients
Surgery
business
Subjects
Details
- ISSN :
- 00411345
- Volume :
- 50
- Database :
- OpenAIRE
- Journal :
- Transplantation Proceedings
- Accession number :
- edsair.doi.dedup.....2b00ec8131653b09bb53df7945e54aab