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Non-Culprit MACE Rate in LRP: The Influence of Optimal Medical Therapy Using DAPT and Statins
- Source :
- Cardiovascular revascularization medicine, 37, 92-96. Elsevier Inc., Cardiovascular Revascularization Medicine, 37, 92-96, Cardiovascular Revascularization Medicine, Cardiovascular Revascularization Medicine, 37, pp. 92-96
- Publication Year :
- 2022
-
Abstract
- Background/Purpose: The Lipid Rich Plaque (LRP) study demonstrated the association between coronary plaque lipid content and outcomes. In this LRP substudy, we assessed the impact of optimal medical therapy (OMT) on the occurrence of non-culprit major adverse cardiac events (NC-MACE). Advanced intracoronary imaging modalities are able to identify patients with vulnerable coronary lesion morphology associated with future events.Methods/Materials: A total of 1270 patients who underwent cardiac catheterization for suspected coronary artery disease (CAD) with evaluable maxLCBI4mm in non-culprit vessels and known medical therapy after discharge were followed for 2 years. OMT was defined as the use of a statin and dual antiplatelet therapy (DAPT).Results: Among the 1270 patients included in this substudy, 1110 (87.7%) had PCI for an index event, and 1014 (80%) patients received OMT. Estimated cumulative incidence functions of NC-MACE did not differ significantly between patients treated with or without OMT (log-rank p-value = 0.876). In patients labeled high risk (maxLCBI4mm > 400), cumulative incidence function also did not differ between patients treated with vs without OMT (log-rank p-value = 0.19).Conclusions: In the current LRP analysis, we could not identify a beneficial effect of OMT in the reduction of NC-MACE rate, even in patients with high-risk plaques during 24-month follow-up.
- Subjects :
- medicine.medical_specialty
Non-culprit major adverse cardiac events
Statin
medicine.drug_class
medicine.medical_treatment
Vascular damage Radboud Institute for Health Sciences [Radboudumc 16]
Coronary Artery Disease
Culprit
Coronary artery disease
Lesion
All institutes and research themes of the Radboud University Medical Center
Percutaneous Coronary Intervention
Internal medicine
medicine
Humans
Cumulative incidence
Optimal medical therapy
Cardiac catheterization
business.industry
Lipid-rich plaque
General Medicine
medicine.disease
Lipids
Plaque, Atherosclerotic
Treatment Outcome
Conventional PCI
Dual antiplatelet therapy
Cardiology
Hydroxymethylglutaryl-CoA Reductase Inhibitors
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Platelet Aggregation Inhibitors
Mace
Subjects
Details
- ISSN :
- 15538389 and 18780938
- Database :
- OpenAIRE
- Journal :
- Cardiovascular revascularization medicine, 37, 92-96. Elsevier Inc., Cardiovascular Revascularization Medicine, 37, 92-96, Cardiovascular Revascularization Medicine, Cardiovascular Revascularization Medicine, 37, pp. 92-96
- Accession number :
- edsair.doi.dedup.....2b0d293eaa1a8286b18546c80aeb2b48