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The role of σ-receptors in levodopa-induced dyskinesia in patients with advanced Parkinson disease: a positron emission tomography study
- Source :
- Journal of Neurosurgery. 100:606-610
- Publication Year :
- 2004
- Publisher :
- Journal of Neurosurgery Publishing Group (JNSPG), 2004.
-
Abstract
- Object. Levodopa-induced dyskinesia (LID) in patients with Parkinson disease (PD) mimics acute dystonic reactions induced by antipsychotic agents, possibly mediated by σ-receptors; however, there are few reports in which the relationship between σ-receptors and LID in advanced PD is investigated. The binding potential of cerebellar σ-receptors before and after a pallidal surgery for dyskinesia in patients with advanced PD is assessed. Methods. Six patients with advanced PD (male/female ratio 3:3, age 56.7 ± 9.8 years) underwent stereotactic pallidal surgery (two posteroventral pallidotomy procedures and four deep brain stimulation of the globus pallidus internus, including one bilateral case). Clinical features of patients with PD were assessed using Hoehn and Yahr (H & Y) stages, the Unified Parkinson's Disease Rating Scale (UPDRS), and the Schwab and England Activities of Daily Life Scale (S & E). The LID was evaluated by LID severity score. The binding potential of cerebellar σ-receptors was determined before and after the surgery by 11C-nemonapride positron emission tomoraphy, a specific radioligand for σ-receptors in the cerebellum. All clinical scores, especially the LID severity score, were dramatically improved after the surgery (p < 0.05). Preoperatively, contralateral cerebellar binding potential was significantly elevated (p < 0.01), and it was reduced after the surgery, but it was still higher than that of healthy volunteers (p < 0.05). The ipsilateral cerebellar binding potential remained unchanged after the surgery. The level of binding potential did not correlate with H & Y stage, UPDRS, or S & E score, but a strong positive correlation was seen between the binding potential and the preoperative LID severity score when the patients were receiving medication (r = 0.893, p < 0.05). Conclusions. Cerebellar σ-receptors may potentially involve the genesis of LID in advanced PD.
- Subjects :
- Male
Dyskinesia, Drug-Induced
medicine.medical_specialty
Levodopa
Deep brain stimulation
medicine.medical_treatment
Electric Stimulation Therapy
Neurological disorder
Globus Pallidus
Severity of Illness Index
Gastroenterology
Antiparkinson Agents
Central nervous system disease
Degenerative disease
Cerebellum
Internal medicine
medicine
Humans
Receptors, sigma
Antipsychotic
Aged
Levodopa-induced dyskinesia
business.industry
Parkinson Disease
Middle Aged
medicine.disease
Surgery
Dyskinesia
Female
medicine.symptom
business
Tomography, Emission-Computed
medicine.drug
Subjects
Details
- ISSN :
- 00223085
- Volume :
- 100
- Database :
- OpenAIRE
- Journal :
- Journal of Neurosurgery
- Accession number :
- edsair.doi.dedup.....2b0fb4005db279745ecb282cfd97ff0e