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Early-life sensitization to hen's egg predicts asthma and rhinoconjunctivitis at 14 years of age
- Source :
- Christiansen, E S, Kjaer, H F, Eller, E, Bindslev-Jensen, C, Høst, A, Mortz, C G & Halken, S 2017, ' Early-life sensitization to hen's egg predicts asthma and rhinoconjunctivitis at 14 years of age ', Pediatric Allergy and Immunology, vol. 28, no. 8, pp. 776–783 . https://doi.org/10.1111/pai.12815
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Background Sensitization to both inhalant and food allergens has been shown to be risk factors for development of asthma and rhinoconjunctivitis (RC). However, few studies have addressed the role of transient or persistent IgE sensitization to specific allergens in early life for later development of allergic diseases. The aim of this study was to explore the association between transient and persistent sensitization in early life and the development of asthma and RC at 6 and 14 years. Methods The Danish Allergy Research Center (DARC) cohort is a prospective non-interventional birth cohort study comprising 562 children. For the purpose of this study, we examined a subgroup of the original cohort with specific IgE measured at, at least 3 of 4 follow-ups between 3 and 18 months of age (n = 366). Multiple logistic regression models were used to investigate the association between transient and persistent early-life sensitization to groups of and to individual allergens and asthma and RC at 6 and 14 years compared to a reference group with no sensitization. Results Both transient early-life sensitization and persistent early-life sensitization to cow's milk or hen's egg proteins were associated with asthma (aOR 3.99[1.41-11.32] and 5.95[1.78-19.92]) and RC (aOR 2.94[1.19-7.28] and 6.18[1.86-20.53]) at 14 years, this association being driven mainly by sensitization to hen's egg. Transient early-life sensitization to house dust mite (HDM) had increased risk of asthma (aOR 3.80[1.17-12.41]) at 14 years. Conclusions Early transient IgE sensitization and persistent IgE sensitization to hen's egg were associated with asthma and RC at 14 years. Furthermore, sensitization to HDM was associated with asthma at 14 years.
- Subjects :
- Male
Allergy
Egg protein
Immunoglobulin E
sensitization
0302 clinical medicine
Risk Factors
Immunology and Allergy
Prospective Studies
030212 general & internal medicine
Child
Prospective cohort study
Sensitization
biology
Asthma/complications
birth cohort
Rhinitis, Allergic/complications
medicine.anatomical_structure
Cohort
Egg Hypersensitivity/complications
Female
Adolescent
Immunology
03 medical and health sciences
transient
Journal Article
medicine
Humans
Egg Hypersensitivity
Conjunctivitis/complications
childhood
Asthma
House dust mite
business.industry
rhinoconjunctivitis
persistent
Infant
asthma
Conjunctivitis
medicine.disease
biology.organism_classification
Rhinitis, Allergic
predictors
Logistic Models
030228 respiratory system
Pediatrics, Perinatology and Child Health
biology.protein
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 09056157
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Pediatric Allergy and Immunology
- Accession number :
- edsair.doi.dedup.....2b24247269a035ca61264999b98b3ebf