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Therapeutic efficacy of rolipram delivered by PgP nanocarrier on secondary injury and motor function in a rat TBI model
- Source :
- Nanomedicine (Lond)
- Publication Year :
- 2022
- Publisher :
- Future Medicine Ltd, 2022.
-
Abstract
- Aim: To develop poly(lactide- co-glycolide)-graft-polyethylenimine (PgP) as a nanocarrier for the delivery of rolipram (Rm) and evaluate the therapeutic efficacy of Rm-loaded PgP (Rm-PgP) on secondary injury and motor function in a rat traumatic brain injury (TBI) model. Materials & methods: Rm-PgP was injected in the injured brain lesion immediately after TBI using a microinjection pump. Secondary injury pathologies such as inflammatory response, apoptosis and astrogliosis were assessed by histological analysis and functional recovery was assessed by assorted motor function tests. Results: Rm-PgP restored cyclic adenosine monophosphate level in the injured brain close to the sham level and Rm-PgP treatment reduced lesion volume, neuroinflammation and apoptosis and improved motor function at 7 days post-TBI. Conclusion: One single injection of Rm-PgP can be effective for acute mild TBI treatment.
- Subjects :
- endocrine system diseases
integumentary system
Biomedical Engineering
Medicine (miscellaneous)
Apoptosis
Bioengineering
Recovery of Function
Development
female genital diseases and pregnancy complications
Rats
carbohydrates (lipids)
Disease Models, Animal
Brain Injuries, Traumatic
polycyclic compounds
Animals
Polyethyleneimine
General Materials Science
Rolipram
Research Article
Subjects
Details
- ISSN :
- 17486963 and 17435889
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Nanomedicine
- Accession number :
- edsair.doi.dedup.....2b3877c329e1a0ea2c9f3f9c18e03479