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COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study
- Source :
- Leukemia, 35(12), 3444-3454. Nature Publishing Group, Leukemia, Chatzikonstantinou, Thomas; Kapetanakis, Anargyros; Scarfò, Lydia; Karakatsoulis, Georgios; Allsup, David; Cabrero, Alejandro Alonso; Andres, Martin; Antic, Darko; Baile, Mónica; Baliakas, Panagiotis; Bron, Dominique; Capasso, Antonella; Chatzileontiadou, Sofia; Cordoba, Raul; Correa, Juan-Gonzalo; Cuéllar-García, Carolina; De Paoli, Lorenzo; De Paolis, Maria Rosaria; Del Poeta, Giovanni; Demosthenous, Christos; ... (2021). COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study. Leukemia, 35(12), pp. 3444-3454. Springer Nature 10.1038/s41375-021-01450-8
- Publication Year :
- 2021
-
Abstract
- Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to Coronavirus disease 2019 (COVID-19) due to age, disease, and treatment-related immunosuppression. We aimed to assess risk factors of outcome and elucidate the impact of CLL-directed treatments on the course of COVID-19. We conducted a retrospective, international study, collectively including 941 patients with CLL and confirmed COVID-19. Data from the beginning of the pandemic until March 16, 2021, were collected from 91 centers. The risk factors of case fatality rate (CFR), disease severity, and overall survival (OS) were investigated. OS analysis was restricted to patients with severe COVID-19 (definition: hospitalization with need of oxygen or admission into an intensive care unit). CFR in patients with severe COVID-19 was 38.4%. OS was inferior for patients in all treatment categories compared to untreated (p
- Subjects :
- Chronic lymphocytic leukaemia
Cancer Research
medicine.medical_specialty
COVID-19 Vaccines
Coronavirus disease 2019 (COVID-19)
Epidemiology
medicine.medical_treatment
Chronic lymphocytic leukemia
CLL, COVID-19
610 Medicine & health
Disease
Lower risk
COVID-19 (Malaltia)
Severity of Illness Index
Article
NO
law.invention
Risk Factors
law
Internal medicine
Case fatality rate
Mortalitat
medicine
Humans
Hematologi
Chronic
Mortality
Science & Technology
Leukemia
SARS-CoV-2
business.industry
Vaccination
B-Cell
Leucèmia
COVID-19
Immunosuppression
Hematology
Prognosis
medicine.disease
Leukemia, Lymphocytic, Chronic, B-Cell
Survival Analysis
Intensive care unit
Lymphocytic
Oncology
business
Life Sciences & Biomedicine
Subjects
Details
- Language :
- English
- ISSN :
- 08876924
- Database :
- OpenAIRE
- Journal :
- Leukemia, 35(12), 3444-3454. Nature Publishing Group, Leukemia, Chatzikonstantinou, Thomas; Kapetanakis, Anargyros; Scarfò, Lydia; Karakatsoulis, Georgios; Allsup, David; Cabrero, Alejandro Alonso; Andres, Martin; Antic, Darko; Baile, Mónica; Baliakas, Panagiotis; Bron, Dominique; Capasso, Antonella; Chatzileontiadou, Sofia; Cordoba, Raul; Correa, Juan-Gonzalo; Cuéllar-García, Carolina; De Paoli, Lorenzo; De Paolis, Maria Rosaria; Del Poeta, Giovanni; Demosthenous, Christos; ... (2021). COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study. Leukemia, 35(12), pp. 3444-3454. Springer Nature 10.1038/s41375-021-01450-8 <http://dx.doi.org/10.1038/s41375-021-01450-8>, Chatzikonstantinou, T, Kapetanakis, A, Scarfò, L, Karakatsoulis, G, Allsup, D, Cabrero, A A, Andres, M, Antic, D, Baile, M, Baliakas, P, Bron, D, Capasso, A, Chatzileontiadou, S, Cordoba, R, Correa, J G, Cuéllar-García, C, De Paoli, L, De Paolis, M R, Del Poeta, G, Demosthenous, C, Dimou, M, Donaldson, D, Doubek, M, Efstathopoulou, M, Eichhorst, B, El-Ashwah, S, Enrico, A, Espinet, B, Farina, L, Ferrari, A, Foglietta, M, Frederiksen, H, Fürstenau, M, García-Marco, J A, García-Serra, R, Gentile, M, Gimeno, E, Glenthøj, A, Gomes da Silva, M, Gutwein, O, Hakobyan, Y K, Herishanu, Y, Hernández-Rivas, J Á, Herold, T, Innocenti, I, Itchaki, G, Jaksic, O, Janssens, A, Kalashnikova, О B, Kalicińska, E, Karlsson, L K, Kater, A P, Kersting, S, Labrador, J, Lad, D, Laurenti, L, Levin, M D, Lista, E, Lopez-Garcia, A, Malerba, L, Marasca, R, Marchetti, M, Marquet, J, Mattsson, M, Mauro, F R, Milosevic, I, Mirás, F, Morawska, M, Motta, M, Munir, T, Murru, R, Niemann, C U, Rodrigues, R N, Olivieri, J, Orsucci, L, Papaioannou, M, Pavlovsky, M A, Piskunova, I, Popov, V M, Quaglia, F M, Quaresmini, G, Qvist, K, Reda, G, Rigolin, G M, Ruchlemer, R, Saghumyan, G, Shrestha, A, Šimkovič, M, Špaček, M, Sportoletti, P, Stanca, O, Stavroyianni, N, Tadmor, T, Te Raa, D, Tonino, S H, Trentin, L, Van Der Spek, E, van Gelder, M, van Kampen, R, Varettoni, M, Visentin, A, Vitale, C, Wasik-Szczepanek, E, Wróbel, T, San Segundo, L Y, Yassin, M, Coscia, M, Rambaldi, A, Montserrat, E, Foà, R, Cuneo, A, Stamatopoulos, K & Ghia, P 2021, ' COVID-19 severity and mortality in patients with CLL : an update of the international ERIC and Campus CLL study ', Leukemia, vol. 35, no. 12, pp. 3444-3454 . https://doi.org/10.1038/s41375-021-01450-8
- Accession number :
- edsair.doi.dedup.....2b4242b259b897d0995751af50c0fbf1