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Non‐thermal atmospheric plasma treatment of onychomycosis in an in vitro human nail model
- Source :
- Mycoses
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- Background Onychomycosis affects almost 6% of the world population. Topical azoles and systemic antifungal agents are of low efficacy and can have undesirable side effects. An effective, non-invasive therapy for onychomycosis is an unmet clinical need. Objective Determine the efficacy threshold of non-thermal atmospheric plasma (NTAP) to treat onychomycosis in an in vitro model. Methods A novel toe/nail-plate model using cadaver nails and agarose media inoculated with Candida albicans was exposed to a range of NTAP doses. Results Direct exposure of C albicans and Trichophyton mentagrophytes to 12 minutes of NTAP results in complete killing at doses of 39 and 15 kPulses, respectively. Onset of reduced viability of C albicans to NTAP treatment through the nail plate occurs at 64 kPulses with 10× and 100× reduction at 212 and 550 kPulses, respectively. Conclusions NTAP is an effective, non-invasive therapeutic approach to onychomycosis that should be evaluated in a clinical setting.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Plasma Gases
030106 microbiology
C. albicans
Dermatology
cold atmospheric plasma
dielectric barrier discharge
In vitro model
Trichophyton mentagrophytes
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
Tinea
Trichophyton
Candida albicans
Onychomycosis
Cadaver
Confidence Intervals
medicine
Non thermal atmospheric plasma
Humans
pulsed electric field
Foot Dermatoses
Dose-Response Relationship, Drug
biology
business.industry
fungus
Candidiasis
Original Articles
General Medicine
Nail plate
biology.organism_classification
In vitro
Infectious Diseases
medicine.anatomical_structure
non‐thermal atmospheric plasma
Nail (anatomy)
Original Article
business
Subjects
Details
- ISSN :
- 14390507 and 09337407
- Volume :
- 63
- Database :
- OpenAIRE
- Journal :
- Mycoses
- Accession number :
- edsair.doi.dedup.....2b4a9d472df075e9da30591696b17493