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CRISPs Function to Boost Sperm Power Output and Motility
- Source :
- Frontiers in Cell and Developmental Biology, Vol 9 (2021), Frontiers in Cell and Developmental Biology
- Publication Year :
- 2021
- Publisher :
- Frontiers Media S.A., 2021.
-
Abstract
- Fertilization requires sperm to travel long distances through the complex environment of the female reproductive tract. Despite the strong association between poor motility and infertility, the kinetics of sperm tail movement and the role individual proteins play in this process is poorly understood. Here, we use a high spatiotemporal sperm imaging system and an analysis protocol to define the role of CRISPs in the mechanobiology of sperm function. Each of CRISP1, CRISP2, and CRISP4 is required to optimize sperm flagellum waveform. Each plays an autonomous role in defining beat frequency, flexibility, and power dissipation. We thus posit that the expansion of the CRISP family from one member in basal vertebrates, to three in most mammals, and four in numerous rodents, represents an example of neofunctionalization wherein proteins with a common core function, boosting power output, have evolved to optimize different aspects of sperm tail performance.
- Subjects :
- 0301 basic medicine
Axoneme
QH301-705.5
Motility
Biology
Flagellum
male fertility
male infertility
Male infertility
03 medical and health sciences
Cell and Developmental Biology
0302 clinical medicine
medicine
crisp
Biology (General)
axoneme
Original Research
Sperm flagellum
urogenital system
sperm function
Cell Biology
medicine.disease
Sperm
Cell biology
030104 developmental biology
Neofunctionalization
flagella
030217 neurology & neurosurgery
Function (biology)
Developmental Biology
Subjects
Details
- Language :
- English
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Frontiers in Cell and Developmental Biology
- Accession number :
- edsair.doi.dedup.....2b54264a1576544ed4cd801e014d5824