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Patchy fur, a mouse coat mutation associated with X-Y nondisjunction, maps to the pseudoautosomal boundary region
- Source :
- Genomics. 54(3)
- Publication Year :
- 1999
-
Abstract
- Patchy fur is a semidominant X-linked mutation in the mouse, resulting in a sparse coat. The Paf mutation also alters the normal segregation of the X and the Y chromosomes during male meiosis by causing nondisjunction at anaphase I. Analysis of 1139 female meioses from an intersubspecific backcross using 15 PCR-based markers localizes Paf to an approximately 0.2-cM interval that includes the pseudoautosomal boundary. The meiotic nondisjunction phenotype may result from a chromosomal rearrangement that includes pseudoautosomal sequences and affects XY pairing.
- Subjects :
- Genetic Markers
Male
X Chromosome
Pseudoautosomal region
Mice, Inbred Strains
Chromosomal rearrangement
Biology
Contig Mapping
Mice
Gene mapping
Meiosis
Genetics
Animals
Chromosomes, Artificial, Yeast
X chromosome
Crosses, Genetic
Anaphase
DNA Primers
Polymorphism, Genetic
Chromosome Mapping
Mice, Mutant Strains
Nondisjunction
Mutation (genetic algorithm)
Mutation
Female
Hair
Subjects
Details
- ISSN :
- 08887543
- Volume :
- 54
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Genomics
- Accession number :
- edsair.doi.dedup.....2b5e23ca8aaf40a45b736df04ff316ff