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Regulation of pulmonary inflammation by mesenchymal cells
- Source :
- Pulmonary Pharmacology & Therapeutics, 29(2), 156-165. ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD
- Publication Year :
- 2013
-
Abstract
- Pulmonary inflammation and tissue remodelling are common elements of chronic respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and pulmonary hypertension (PH). In disease, pulmonary mesenchymal cells not only contribute to tissue remodelling, but also have an important role in pulmonary inflammation. This review will describe the immunomodulatory functions of pulmonary mesenchymal cells, such as airway smooth muscle (ASM) cells and lung fibroblasts, in chronic respiratory disease. An important theme of the review is that pulmonary mesenchymal cells not only respond to inflammatory mediators, but also produce their own mediators, whether pro-inflammatory or pro-resolving, which influence the quantity and quality of the lung immune response. The notion that defective pro-inflammatory or pro-resolving signalling in these cells potentially contributes to disease progression is also discussed. Finally, the concept of specifically targeting pulmonary mesenchymal cell immunomodulatory function to improve therapeutic control of chronic respiratory disease is considered. (C) 2014 Elsevier Ltd. All rights reserved.
- Subjects :
- Pulmonary and Respiratory Medicine
Lung Diseases
Macrophage
medicine.medical_treatment
TISSUE GROWTH-FACTOR
Respiratory System
T-LYMPHOCYTE ADHESION
Biology
Mast cell
Idiopathic pulmonary fibrosis
AIRWAY SMOOTH-MUSCLE
medicine
Animals
Humans
Pharmacology (medical)
MAST-CELL
Cell adhesion molecule (CAM)
Cytokine
PROTEASE-ACTIVATED RECEPTOR-1
COPD
Lung
Mesenchymal Stromal Cells
Extracellular matrix (ECM)
Biochemistry (medical)
Respiratory disease
Mesenchymal stem cell
TGF-BETA
Mesenchymal Stem Cells
Pneumonia
medicine.disease
TNF-ALPHA
Pulmonary hypertension
HUMAN LUNG FIBROBLASTS
respiratory tract diseases
medicine.anatomical_structure
Chemokine
ANNEXIN A2
Immunology
Airway Remodeling
SEVERE ASTHMA
Subjects
Details
- ISSN :
- 15229629 and 10945539
- Volume :
- 29
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Pulmonary pharmacologytherapeutics
- Accession number :
- edsair.doi.dedup.....2b5eca9ae854861332cdade3ba9510ff