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Changes of peripheral lymphocyte subsets and cytokine environment during aging and deteriorating gastrointestinal tract health status
- Source :
- Oncotarget
- Publication Year :
- 2017
- Publisher :
- Impact Journals LLC, 2017.
-
Abstract
- Human immune senescence accompanies with the physical and physiological frailty. The functional change and shift of NK, NKT and T cell subsets by aging have been widely studied. However, it remains largely unclear how the aging and disease conditions affect the distribution of lymphocytes. In the present study, 233 subjects with age range from 20 to 87 year old, including healthy people, people with chronic gastrointestinal tract disease or cancers were investigated. We found that the proportion of NK cells, CD8+ T cells and NKT cells remained relatively unchanged with aging. However, NKG2D and CD16 expression level on NK cells decreased with aging indicating impaired NK cell function. Surprisingly, the proportion of NK, NKT and T cells all declined with deteriorating health status from health to chronic gastrointestinal tract disease and cancer. Furthermore, cytokine and chemokine profiles changed with aging, but did not vary with different health status. Our results highlight new evidence for a continuum of change during immunologic aging and show unique data for variations of NK cells, CD8+ T cells, NKT cells, and cytokine microenvironment with human aging and health status transformation.
- Subjects :
- 0301 basic medicine
Chemokine
medicine.medical_treatment
T cell
T cells
Disease
NK cells
03 medical and health sciences
Research Paper: Gerotarget (Focus on Aging)
medicine
Gastrointestinal tract
biology
gastrointestinal tract disease
business.industry
Gerotarget
aging
Natural killer T cell
NKG2D
NKT cells
030104 developmental biology
Cytokine
medicine.anatomical_structure
Oncology
Immunology
biology.protein
business
CD8
Subjects
Details
- Language :
- English
- ISSN :
- 19492553
- Volume :
- 8
- Issue :
- 37
- Database :
- OpenAIRE
- Journal :
- Oncotarget
- Accession number :
- edsair.doi.dedup.....2b8aba6a135be379fad83749d3aacade