Back to Search
Start Over
Association of advanced glycation end products with diabetic retinopathy in type 2 diabetes mellitus
- Source :
- Diabetes research and clinical practice. 177
- Publication Year :
- 2020
-
Abstract
- Advanced glycation end products (AGEs) were reported to be associated with diabetes development and diabetes related complications when accumulated in high levels. This study investigated the association between AGEs and diabetic retinopathy (DR).A total of 1,471 patients with type 2 diabetes were enrolled. Fundus radiography was used for DR measurement. AGEs were detected through non-invasive skin autofluorescence method.Patients with more advanced DR showed a much higher AGEs, and the prevalence of DR (based on the severity) increase with ascending AGEs quartiles (all P for trend 0.001). The multivariable-adjusted odds ratios of any DR across AGEs quartiles were 1.00, 1.69 (95% confidence interval [CI] 1.16-2.47), 1.58 (95%CI 1.06-2.37) and 1.60 (95%CI 1.05-2.44) (P for trend = 0.044), respectively. Similar results were found in vision-threatening DR (VTDR) subgroup (P for trend = 0.009). When AGEs was considered as a continuous variable by using restricted cubic splines, a graded positive association of AGEs with the odds of any presence of DR was observed (P for trend 0.001). Further, we found that AGEs presented the similar predictive value for any DR with glycated hemoglobin ANon-invasive measured skin AGEs, associated with the prevalence of all stages of DR, might be a more suitable indicator than HbA
- Subjects :
- Glycation End Products, Advanced
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
030209 endocrinology & metabolism
Type 2 diabetes
Fundus (eye)
03 medical and health sciences
0302 clinical medicine
Endocrinology
Glycation
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Humans
030212 general & internal medicine
Glycated Hemoglobin
Diabetic Retinopathy
business.industry
Type 2 Diabetes Mellitus
General Medicine
Diabetic retinopathy
Skin autofluorescence
medicine.disease
Cross-Sectional Studies
Diabetes Mellitus, Type 2
Diabetes-Related Complications
business
Subjects
Details
- ISSN :
- 18728227
- Volume :
- 177
- Database :
- OpenAIRE
- Journal :
- Diabetes research and clinical practice
- Accession number :
- edsair.doi.dedup.....2b9958f04cdaffb1de6f85f17e2fe7d5