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Effect of intravitreal ranibizumab injections on aqueous humour concentrations of vascular endothelial growth factor and pigment epithelium-derived factor in patients with myopic choroidal neovascularisation
- Publication Year :
- 2015
-
Abstract
- Aims To investigate aqueous humour changes in vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) levels in patients with choroidal neovascularisation (CNV) secondary to pathological myopia (mCNV) before and after intravitreal ranibizumab injection (IVR). Methods This was a prospective, case–control study investigating aqueous levels of VEGF and PEDF in eyes with mCNV treated with IVR. Results Mean VEGF and PEDF levels in the aqueous humour of control patients were 25.7±4.9 pg/mL and 12.6±3.5 ng/mL, respectively. Lower levels of both VEGF (19.5±5.4 pg/mL) and PEDF (4.7±2.2 ng/mL) were found in patients with mCNV before IVR. After IVR, aqueous VEGF levels significantly reduced to 6.5±2.7 pg/mL, while PEDF levels significantly increased to 35.8±11.4 ng/mL. VEGF and PEDF levels significantly correlated with each other, and with best-corrected visual acuity and central retinal thickness. Conclusions The VEGF and PEDF levels in aqueous humour were significantly lower in the myopic group than in controls. Moreover, IVR resulted in reduced VEGF and increased PEDF levels in patients with mCNV. In mCNV, neovascularisation is associated with inappropriate VEGF and PEDF expression. A balance between VEGF and PEDF is crucial to prevent CNV development. Trial registration number NCT02175940.
- Subjects :
- Male
Vascular Endothelial Growth Factor A
genetic structures
myopic choroidal neovascularisation
Visual Acuity
Angiogenesis Inhibitors
chemistry.chemical_compound
Monoclonal
Myopia
Prospective Studies
Humanized
Degenerative
PEDF
choroidal neovascularization
pathologic myopia
ranibizumab
Middle Aged
Sensory Systems
Vascular endothelial growth factor
Vascular endothelial growth factor A
medicine.anatomical_structure
Choroidal neovascularization
Intravitreal Injections
Myopia, Degenerative
Female
medicine.symptom
medicine.drug
Aged
Antibodies, Monoclonal, Humanized
Aqueous Humor
Case-Control Studies
Choroidal Neovascularization
Enzyme-Linked Immunosorbent Assay
Eye Proteins
Humans
Nerve Growth Factors
Protease Inhibitors
Ranibizumab
Serpins
medicine.medical_specialty
Ophthalmology
Cellular and Molecular Neuroscience
Antibodies
medicine
Aqueous humour
business.industry
Retinal
eye diseases
chemistry
sense organs
Choroid
business
Subjects
Details
- Language :
- English
- ISSN :
- 02175940
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....2bbcb752d4e45ad8bc3ee77ec2f5a32e