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The impact of HIV viral control on the incidence of HIV-associated anal cancer
- Source :
- Journal of acquired immune deficiency syndromes (1999). 63(5)
- Publication Year :
- 2013
-
Abstract
- BACKGROUND Recent studies have shown that the incidence of squamous cell cancer of the anus (SCCA) has increased in the combined antiretroviral therapy (cART) era. The effect of undetectable HIV viral loads as a result of successful cART has not been evaluated. METHODS We performed a retrospective cohort study among male US veterans diagnosed with HIV and followed between 1985 and 2009 using the Veterans Affairs Immunologic Case Registry (VA-ICR). We calculated age-adjusted incidence rates and rate ratios for SCCA. We conducted Cox proportional hazards ratios of SCCA in a multivariable model including time-varying covariates of nadir CD4 count and overall percentage of time with an undetectable HIV viral load. RESULTS The age-adjusted SCCA incidence rate among the group who ever received cART was 146.8/100,000 person-years (95% confidence interval, 124.1 to 172.6) and was not significantly higher than the SCCA rate of those who never received cART (134.3/100,000 person-years; 95% confidence interval, 112.5 to 159.0). In a multivariable model limited to veterans who had ever received cART (adjusted for demographic variables, nadir, and most recent CD4 counts) individuals who had 61%-80% or 81%-100% of follow-up time with undetectable HIV viral loads had significantly decreased SCCA risk compared with those who had undetectable HIV viral loads
- Subjects :
- Cart
Adult
Male
medicine.medical_specialty
HIV Infections
Article
Cohort Studies
Internal medicine
medicine
Anal cancer
Humans
Pharmacology (medical)
Veterans Affairs
Aged
Retrospective Studies
Veterans
business.industry
Proportional hazards model
Incidence (epidemiology)
Incidence
virus diseases
Retrospective cohort study
Odds ratio
Middle Aged
Viral Load
medicine.disease
Anus Neoplasms
United States
Infectious Diseases
Anti-Retroviral Agents
Immunology
Carcinoma, Squamous Cell
business
Viral load
Subjects
Details
- ISSN :
- 19447884
- Volume :
- 63
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of acquired immune deficiency syndromes (1999)
- Accession number :
- edsair.doi.dedup.....2bd65427387ff1be1b99d53e70d1c7bd