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Handling (Nano)Silver as Antimicrobial Agent: Therapeutic Window, Dissolution Dynamics, Detection Methods and Molecular Interactions
- Source :
- Chemistry – A European Journal. 26:10948-10971
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Silver is an antimicrobial agent well known since antiquity. With the emergence of multiresistant bacteria, it has come back into the focus of research, and ionic as well as nano-sized silver have been studied in vitro and in vivo. The results are controversial, silver being discussed as the "silver bullet" or a "wolf in sheep's clothing". A thorough search of literature from chemistry, materials and environmental science, biology and medicine led to this Review which summarizes the potential use of silver and its compounds in medicine, ongoing processes of dissolution and the different methods by which this usefulness can be evaluated. It also highlights the therapeutic window of silver, mechanistic interactions of silver and biological media as well as best practices for handling silver in a biomedical environment. This Review reflects the current knowhow and observations, and may thus give hints and guidelines to understand and interpret the observed effects.
- Subjects :
- Therapeutic window
Molecular interactions
Silver
Bacteria
010405 organic chemistry
Chemistry
Organic Chemistry
Silver Nano
Metal Nanoparticles
Nanotechnology
General Chemistry
Multiresistant bacteria
010402 general chemistry
Antimicrobial
01 natural sciences
Catalysis
0104 chemical sciences
Anti-Infective Agents
Solubility
Silver bullet
Biological media
Subjects
Details
- ISSN :
- 15213765 and 09476539
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Chemistry – A European Journal
- Accession number :
- edsair.doi.dedup.....2bd7d630ea98ae430a1dfbdc7581f64e