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Impaired vasodilation of peripheral arteries in response to acetylcholine in human beings with abdominal aortic aneurysm
- Source :
- Journal of vascular surgery. 20(5)
- Publication Year :
- 1994
-
Abstract
- Purpose: Most aneurysms are generally presumed to be atherosclerotic in origin. Endothelium-dependent dilations were impaired in the cases of atherosclerosis. It is not clear whether the endothelial function of the peripheral arteries in humans with abdominal aortic aneurysm is impaired. The purpose of this study is to characterize endothelium-dependent relaxations in patients with abdominal aortic aneurysm. Methods: Responses of external iliac artery blood flow to acetylcholine (30 μg/min: an endothelium-dependent vasodilator) and sodium nitroprusside (10 μg/min: a direct dilator of smooth muscle) were examined by electromagnetic blood flow meter in a group of 13 patients consisting of six patients with abdominal aortic aneurysm, six patients with colorectal cancer, and one patient with abdominal aortic aneurysm and rectal cancer. Results: The mean blood flow before administration of drugs was comparable between the two groups. In the patients with abdominal aortic aneurysm, infusion of acetylcholine did not significantly increase the mean blood flow, whereas in the patients with colorectal cancer, acetylcholine increased the blood flow significantly. The increases of blood flow by an infusion of sodium nitroprusside were comparable between the two groups. In one patient with abdominal aortic aneurysm and rectal cancer, acetylcholine did not alter the blood flow, and sodium nitroprusside increased the blood flow, which was similar to what the patient with abdominal aortic aneurysm experienced. Conclusions: These results suggest that in patients with abdominal aortic aneurysm, the endothelium-dependent vasodilations of the peripheral artery were impaired without changing the smooth muscle property. (J VASC SURG 1994;20:803-7.)
- Subjects :
- Male
Nitroprusside
medicine.medical_specialty
Vasodilation
Iliac Artery
Aneurysm
medicine.artery
Internal medicine
medicine
Humans
Infusions, Intra-Arterial
Aged
business.industry
Vascular disease
Rectal Neoplasms
Abdominal aorta
Blood flow
Middle Aged
medicine.disease
Abdominal aortic aneurysm
Acetylcholine
Surgery
medicine.anatomical_structure
cardiovascular system
Cardiology
Female
Sodium nitroprusside
Endothelium, Vascular
Cardiology and Cardiovascular Medicine
business
Colorectal Neoplasms
Rheology
Electromagnetic Phenomena
Blood Flow Velocity
Artery
medicine.drug
Aortic Aneurysm, Abdominal
Subjects
Details
- ISSN :
- 07415214
- Volume :
- 20
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of vascular surgery
- Accession number :
- edsair.doi.dedup.....2be6adba5f14b510ab75a0eb30dd6006