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Functional neuroimaging of recovery from motor conversion disorder:A case report
- Source :
- Dogonowski, A-M, Andersen, K W, Sellebjerg, F, Schreiber, K, Madsen, K H & Siebner, H R 2019, ' Functional neuroimaging of recovery from motor conversion disorder : A case report ', NeuroImage, vol. 190, pp. 269-274 . https://doi.org/10.1016/j.neuroimage.2018.03.061
- Publication Year :
- 2019
-
Abstract
- A patient with motor conversion disorder presented with a functional paresis of the left hand. After exclusion of structural brain damage, she was repeatedly examined with whole-brain functional magnetic resonance imaging, while she performed visually paced finger-tapping tasks. The dorsal premotor cortex showed a bilateral deactivation in the acute-subacute phase. Recovery from unilateral hand paresis was associated with a gradual increase in task-based activation of the dorsal premotor cortex bilaterally. The right medial prefrontal cortex displayed the opposite pattern, showing initial task-based activation that gradually diminished with recovery. The inverse dynamics of premotor and medial prefrontal activity over time were found during unimanual finger-tapping with the affected and non-affected hand as well as during bimanual finger-tapping. These observations suggest that reduced premotor and increased medial prefrontal activity reflect an effector-independent cortical dysfunction in conversion paresis which gradually disappears in parallel with clinical remission of paresis. The results link the medial prefrontal and dorsal premotor areas to the generation of intentional actions. We hypothesise that an excessive ‘veto’ signal generated in medial prefrontal cortex along with decreased premotor activity might constitute the functional substrate of conversion disorder. This notion warrants further examination in a larger group of affected patients.
- Subjects :
- Adult
Cognitive Neuroscience
Prefrontal Cortex
Brain damage
Motor Activity
050105 experimental psychology
Fingers
Premotor cortex
03 medical and health sciences
0302 clinical medicine
Functional neuroimaging
Humans
Medicine
0501 psychology and cognitive sciences
Prefrontal cortex
Conversion disorder
Paresis
medicine.diagnostic_test
business.industry
Functional Neuroimaging
05 social sciences
Motor Cortex
Recovery of Function
medicine.disease
Magnetic Resonance Imaging
medicine.anatomical_structure
Conversion Disorder
Neurology
Female
medicine.symptom
Gradual increase
business
Functional magnetic resonance imaging
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Dogonowski, A-M, Andersen, K W, Sellebjerg, F, Schreiber, K, Madsen, K H & Siebner, H R 2019, ' Functional neuroimaging of recovery from motor conversion disorder : A case report ', NeuroImage, vol. 190, pp. 269-274 . https://doi.org/10.1016/j.neuroimage.2018.03.061
- Accession number :
- edsair.doi.dedup.....2c04a626e631c8e5008f1a216d27dc49