Back to Search
Start Over
Genetic impairment of autophagy intensifies expanded polyglutamine toxicity in Caenorhabditis elegans
- Source :
- Biochemical and Biophysical Research Communications. 368:729-735
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- Neuronal homeostasis requires a balance between anabolic and catabolic processes. Eukaryotic cells use two distinct systems for the degradation of unused proteins: the ubiquitin-proteasome system and the autophagic system. The autophagic system is also necessary for the degradation of bulk amounts of proteins and organelles. We have searched for new autophagy-related genes in the Caenorhabditis elegans genome and investigated their role in a polyglutamine (polyQ) disease model. Here, we have shown that inactivation of these genes intensified the toxicity of expanded polyQ in C. elegans neurons and muscles, and at the same time inactivation of CeTor reduced the polyQ toxicity.
- Subjects :
- Catabolism
Autophagy
Biophysics
Cell Biology
Biology
biology.organism_classification
Biochemistry
Genome
Cell biology
Disease Models, Animal
RNA interference
Organelle
Toxicity
Animals
Heredodegenerative Disorders, Nervous System
Genetic Predisposition to Disease
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Peptides
Molecular Biology
Gene
Subjects
Details
- ISSN :
- 0006291X
- Volume :
- 368
- Database :
- OpenAIRE
- Journal :
- Biochemical and Biophysical Research Communications
- Accession number :
- edsair.doi.dedup.....2c1497a55ccf801fbea0bf505624841d