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Phenylboronic Acid-Based Complex Micelles with Enhanced Glucose-Responsiveness at Physiological pH by Complexation with Glycopolymer
- Source :
- Biomacromolecules. 13:3409-3417
- Publication Year :
- 2012
- Publisher :
- American Chemical Society (ACS), 2012.
-
Abstract
- Polymeric nanoparticles with glucose-responsiveness under physiological conditions are of great interests in developing drug delivery system for the treatment of diabetes. Herein, glucose-responsive complex micelles were prepared by self-assembly of a phenylboronic acid-contained block copolymer PEG-b-P(AA-co-APBA) and a glycopolymer P(AA-co-AGA) based on the covalent complexation between phenylboronic acid and glycosyl. The formation of the complex micelles with a P(AA-co-APBA)/P(AA-co-AGA) core and a PEG shell was confirmed by HNMR analysis. The glucose-responsiveness of the complex micelles was investigated by monitoring the light scattering intensity and the fluorescence (ARS) of the micelle solutions. The complex micelles displayed an enhanced glucose-responsiveness compared to the simple PEG-b-P(AA-co-APBA) micelles and the sensitivity of the complex micelles to glucose increased with the decrease of the amount of P(AA-co-AGA) in the compositions. The cytotoxicity of the polymers and the complex micelles was also evaluated by MTT assay. This kind of complex micelles may be an excellent candidate for insulin delivery and may find application in the treatment of diabetes.
- Subjects :
- Models, Molecular
Polymers and Plastics
Cell Survival
Polymers
Glycopolymer
Bioengineering
Micelle
Biomaterials
Structure-Activity Relationship
chemistry.chemical_compound
PEG ratio
Polymer chemistry
Materials Chemistry
Copolymer
Humans
Organic chemistry
Glycosyl
Phenylboronic acid
Micelles
Dose-Response Relationship, Drug
Molecular Structure
Hydrogen-Ion Concentration
Boronic Acids
Glucose
HEK293 Cells
chemistry
Covalent bond
Drug delivery
Subjects
Details
- ISSN :
- 15264602 and 15257797
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Biomacromolecules
- Accession number :
- edsair.doi.dedup.....2c15dcaeb42e3b38b148333e8ec6d2ce