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Endoscopic ultrasound-guided fine needle aspiration cytology of pancreatic adenocarcinomas revisited. A detailed cytological analysis
- Source :
- Journal of Cytology, Vol 38, Iss 1, Pp 31-37 (2021), Journal of Cytology
- Publication Year :
- 2021
- Publisher :
- Wolters Kluwer Medknow Publications, 2021.
-
Abstract
- Background: Early detection of pancreatic adenocarcinomas is essential for improving survival. In this regard, endoscopic ultrasound-guided fine-needle aspiration cytology (EUS-FNAC) has established itself as the method of choice for its ability to target lesions smaller than those which could be targeted by the traditional imaging methods like transabdominal ultrasound. Identifying these tumors correctly on FNA may be challenging because pancreatic adenocarcinomas may show a wide range of morphological features and the presence of contaminants from the gastrointestinal tract may show up as potential pitfalls. This study presents detailed cytomorphological analyses of 59 cases reported as pancreatic adenocarcinomas on smears and cell blocks. The clinical and histopathology follow-up data wherever available have also been presented. Materials and Methods: EUS-FNAC smears and cell blocks from cases reported as pancreatic adenocarcinomas were retrospectively evaluated with individual assessments of a range of features related to cellularity, cellular arrangement, cytoplasmic qualities, and nuclear features. Aspirates from peripancreatic lymph nodes, histopathology sections, and clinical records were reviewed wherever available. Results: Nonneoplastic cells like pancreatic ductal cells and acinar cells, duodenal, and gastric epithelia were detected along with neoplastic cells showing a wide range of variations in different cytomorphological characters. Often, a mixture of features was noted in the same case. Cell block preparations served as useful adjuncts since they made it possible to render unequivocal diagnoses of malignancies in cases where smears were hypocellular. Conclusion: The study creates a useful knowledge base of cytomorphological features of pancreatic adenocarcinomas.
- Subjects :
- Endoscopic ultrasound
Pathology
medicine.medical_specialty
Histology
adenocarcinoma
medicine.diagnostic_test
business.industry
lcsh:Cytology
Early detection
endoscopic_ultrasound_guided_fnac
Transabdominal ultrasound
medicine.disease
Pathology and Forensic Medicine
Aspiration cytology
fnac
medicine.anatomical_structure
Fine needle aspiration cytology
medicine
Adenocarcinoma
Original Article
Histopathology
pancreas
lcsh:QH573-671
Pancreas
business
Subjects
Details
- Language :
- English
- ISSN :
- 09709371
- Volume :
- 38
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of Cytology
- Accession number :
- edsair.doi.dedup.....2c4477e2d7c4d87c36bb83b0109dce9d