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A Novel Imaging Biomarker for Cerebral Small Vessel Disease Associated With Cognitive Impairment: The Deep-Medullary-Veins Score
- Source :
- Frontiers in Aging Neuroscience, Frontiers in Aging Neuroscience, Vol 13 (2021)
- Publication Year :
- 2021
-
Abstract
- Objective: To explore the biomarkers of cerebral small vessel disease (CSVD) associated with cognitive impairment.Methods: A total of 69 patients with CSVD were enrolled in the study, and baseline clinical and imaging data were reviewed retrospectively. The following neuroimaging biomarkers of CSVD were identified: high-grade white matter hyperintensity (HWMH), cerebral microbleeds (CMB), enlarged perivascular space (PVS), and lacunar infarct (LI). A total score for CSVD was calculated. The deep medullary veins (DMVs) were divided into six segments according to the regional anatomy. The total DMV score (0–18) was derived from the sum of the scores of the six individual segments, the scores of which ranged from 0 to 3, for a semiquantitative assessment of the DMV that was based on segmental continuity and visibility.Results: The DMV score, patient age, and total CSVD score were independently associated with the presence or absence of cognitive impairment in patients with CSVD (P < 0.05). By integrating patient age and the total CSVD and DMV scores, the area under the curve of the receiver operating characteristic curve (AUROC) for predicting CSVD associated with cognitive impairment was 0.885, and the sensitivity and specificity were 64.71 and 94.23%, respectively.Conclusions: The DMV score may be a novel imaging biomarker for CSVD associated with cognitive impairment. The integration of the DMV score with age and total CSVD score should increase the predictive value of the DMV score for CSVD associated with cognitive impairment.
- Subjects :
- medicine.medical_specialty
Regional anatomy
Receiver operating characteristic
Imaging biomarker
Medullary cavity
business.industry
cerebral small vessel disease
Cognitive Neuroscience
aging
Area under the curve
Neurosciences. Biological psychiatry. Neuropsychiatry
Disease
deep medullary veins
Internal medicine
medicine
Cardiology
Small vessel
Cognitive impairment
business
total CSVD score CSVD and DMVs
RC321-571
Neuroscience
Original Research
cognitive impairment
Subjects
Details
- ISSN :
- 16634365
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Frontiers in aging neuroscience
- Accession number :
- edsair.doi.dedup.....2c53b68a42af87d58167dbad0bf3af63