Mouse Immunoglobulin Allotypes: Detection with Rabbit Antiserums

Authors :: John E. Coe
Source :: Science. 155:562-567
Publication Year :: 1967
Publisher :: American Association for the Advancement of Science (AAAS), 1967.
Abstract: An antiserum with allotypic specificity for mouse gamma(2a)-globulins was prepared in a rabbit by injection of 7S gamma(2)-globulin of C(57)BL/6 mice. The antibody reacted with an isoantigen in the 7S gamma(2)-globulins of normal serum of mouse strains belonging to the lg-1(b) allotype class (C(57)BL/6, C(57)BL/10, and SJL strains). No precipitin reaction was observed with serum from 18 other inbred mice strains representing other lg-1 allotype classes.