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Prognostic analysis and clinical characteristics of dual primary lung cancer: a population study based on surveillance, epidemiology, and end results (SEER) database
- Source :
- General Thoracic and Cardiovascular Surgery. 70:740-749
- Publication Year :
- 2022
- Publisher :
- Springer Science and Business Media LLC, 2022.
-
Abstract
- Background: The peculiarity and the lack of clinical studies of dual primary lung cancer (DPLC) led to limited knowledge about its clinical characteristics and prognosis. The current study performed a retrospective analysis and established a prognostic nomogram to assess the prognostic factors and clinical characteristics of DPLC.Methods: A total of 1419 DPLC patients with pathological confirmation from SEER were selected and analyzed by univariate and multivariable Cox regression analyses. The independent prognostic factors were included to establish a nomogram. The accuracy and reliability of prognostic model were evaluated by C-indexes, calibration plots, receiver operating characteristic (ROC) curves, decision curve analyses (DCA) and integrated discrimination improvement (IDI) scores. Chi-square test was used to assess the differences between DPLC and single primary lung cancer (SPLC) or synchronous DPLC (sDPLC) and metachronous DPLC (mDPLC).Results: Cox regression analysis showed that age, sex, histological type, stage, LN metastasis, surgery, chemotherapy were independent prognostic factors, we included these factors to establish a prognostic model. In the training cohort, the C-index was 0.690, and the area under curves (AUC) of 3- and 5-year survival time were 0.720 and 0.723. The calibration plots in training cohort and validation cohort were in excellent agreement. DCA and IDI showed that the predictive effect of the novel prognostic model was better than the model based on 8th AJCC TNM system. Chi-square test indicated that DPLC and SPLC had statistical differences on pathological and clinical features.Conclusions: The clinical and pathological characteristics of DPLC were different from the SPLC. The nomogram based on significant factors could provide accurate and individualized survival predictions for DPLC.
- Subjects :
- Oncology
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Lung Neoplasms
business.industry
Seer database
Reproducibility of Results
General Medicine
DUAL (cognitive architecture)
medicine.disease
Prognosis
Internal medicine
Lymphatic Metastasis
medicine
Surveillance, Epidemiology, and End Results
Population study
Humans
Surgery
Lung cancer
business
Cardiology and Cardiovascular Medicine
Proportional Hazards Models
Retrospective Studies
SEER Program
Subjects
Details
- ISSN :
- 18636713 and 18636705
- Volume :
- 70
- Database :
- OpenAIRE
- Journal :
- General Thoracic and Cardiovascular Surgery
- Accession number :
- edsair.doi.dedup.....2c5c585a25a6ae403fccc9c232ebf00b