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Recombinant protein vaccines produced in insect cells
- Source :
- Vaccine
- Publication Year :
- 2012
- Publisher :
- Elsevier Ltd., 2012.
-
Abstract
- Highlights ► BEVS has matured into a commercial manufacturing technology. ► A broad range of vaccines can be produced in a universal “plug and play” process. ► Vaccines can be produced at affordable prices. ► BEVS can offer sustainability of vaccine supply.<br />The baculovirus-insect cell expression system is a well known tool for the production of complex proteins. The technology is also used for commercial manufacture of various veterinary and human vaccines. This review paper provides an overview of how this technology can be applied to produce a multitude of vaccine candidates. The key advantage of this recombinant protein manufacturing platform is that a universal “plug and play” process may be used for producing a broad range of protein-based prophylactic and therapeutic vaccines for both human and veterinary use while offering the potential for low manufacturing costs. Large scale mammalian cell culture facilities previously established for the manufacturing of monoclonal antibodies that have now become obsolete due to yield improvement could be deployed for the manufacturing of these vaccines. Alternatively, manufacturing capacity could be established in geographic regions that do not have any vaccine production capability. Dependent on health care priorities, different vaccines could be manufactured while maintaining the ability to rapidly convert to producing pandemic influenza vaccine when the need arises.
- Subjects :
- Insecta
Cell Culture Techniques
Vaccine Production
Biology
Article
law.invention
law
Animals
Technology, Pharmaceutical
Baculovirus
Insect cells
Vaccines, Synthetic
Insect cell
Recombinant
General Veterinary
General Immunology and Microbiology
business.industry
Protein
fungi
Public Health, Environmental and Occupational Health
Pandemic influenza
food and beverages
Recombinant Proteins
Biotechnology
Infectious Diseases
Pharmaceutical economics
Recombinant DNA
Geographic regions
Molecular Medicine
business
Vaccine
Baculoviridae
Subjects
Details
- Language :
- English
- ISSN :
- 18732518 and 0264410X
- Volume :
- 30
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Vaccine
- Accession number :
- edsair.doi.dedup.....2c5dea4f61338440a15b618a2dd88271