SIGNIFICANCE OF PROLACTIN & CREATINE PHOSPHOKINASE IN EPILEPSY (GRAND MAL) AND PSEUDO SEIZURES IN FEMALE POPULATION

Back Ground & Objectives: One of the important neurological disorders: Epilepsy is marked by sudden recurrent episodes of sensory instabilities, unconsciousness, or convulsions linked with abnormal actions of the brain. Review of literature exposed very partial research studies considering a combination of and serum Prolactin (PRL) and Creatine Phospho kinase (CPK) and as markers for differentiating epileptic and psychogenic non epileptic seizures (PNES). Therefore, in the present study, we analysed the role of serum PRL and CPK, individually and in combination to evaluate the significance of the levels of PRL & CPK in female Patients of Grand Mal epilepsy and Pseudo seizures. Methodology: We conducted this cross-sectional study in a tertiary care medical teaching hospital over a period of 2 years after getting ethical approval from Advance Studies & Research board. We recruited ninety female subjects in our study and divided them in three groups, each of which comprised of 30 subjects. Statistical analyses were done using SPSS 21. ANOVA was used to compare the results of the different groups. P< 0.001was taken as significant Results: The results of this study showed significant difference between the levels of PRL & CPK among three groups. Both PRL & CPK were found higher in epileptic group as compared to pseudo-seizures and control group (p <0.001) Conclusion: The study concluded that both Prolactin & Creatine Phosphokinase may be used as reliable biochemical marker in the diagnosis of grand mal seizures in females and segregating it from pseudo-seizures in female patients. Key words: Creatine Phosphokinase, Prolactin, Generalized Tonic-Clonic Seizures, Pseudo-Seizures