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Nucleic Acid Aptamers for Molecular Diagnostics and Therapeutics: Advances and Perspectives
- Source :
- Angewandte Chemie. 133:2249-2259
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- The advent of SELEX (systematic evolution of ligands by exponential enrichment) technology has shown the ability to evolve artificial ligands with affinity and specificity able to meet growing clinical demand for probes that can, for example, distinguish between the target leukemia cells and other cancer cells within the matrix of heterogeneity, which characterizes cancer cells. Though antibodies are the conventional and ideal choice as a molecular recognition tool for many applications, aptamers complement the use of antibodies due to many unique advantages, such as small size, low cost, and facile chemical modification. This Minireview will focus on the novel applications of aptamers and SELEX, as well as opportunities to develop molecular tools able to meet future clinical needs in biomedicine.
- Subjects :
- Cancer classification
010405 organic chemistry
Computer science
business.industry
Aptamer
General Chemistry
Computational biology
General Medicine
Aptamers, Nucleotide
010402 general chemistry
Molecular diagnostics
01 natural sciences
Catalysis
0104 chemical sciences
Molecular recognition
Nucleic Acids
Nucleic acid
Humans
Biomarker discovery
Pathology, Molecular
business
Biomedicine
Systematic evolution of ligands by exponential enrichment
Subjects
Details
- ISSN :
- 15213757 and 00448249
- Volume :
- 133
- Database :
- OpenAIRE
- Journal :
- Angewandte Chemie
- Accession number :
- edsair.doi.dedup.....2c754ffad6f9492b8bd367b01acee3a5