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IRW and IQW Reduce Colitis-Associated Cancer Risk by Alleviating DSS-Induced Colonic Inflammation
- Source :
- BioMed Research International, BioMed Research International, Vol 2019 (2019)
- Publication Year :
- 2019
- Publisher :
- Hindawi, 2019.
-
Abstract
- Background and Objective. Bioactive peptides exert great influence in animals and human health by targeting gastrointestinal tracts. The colitis model of mice was induced by dextran sulfate sodium (DSS). Thirty-two 8-week-old mice weighing 23 g on average were randomly assigned to four groups of 8 each: mice fed basal diet (CON), mice fed basal diet with 5% DSS (DSS), mice fed 0.03% IRW with 5% DSS (IRW-DSS), and mice fed 0.03% IRW with 5% DSS (IQW-DSS). After an adaptation period of 3 days, on day 8, all mice were slaughtered. Serum samples were collected to determine the level of amino acids; colonic tissue was quick-frozen for the determination of gene expression. Methods. The aim of this study was to assess the ability of two kinds of peptides (IRW and IQW) to repair intestinal inflammatory in the DSS-induced model in accordance with serum amino acids and intestinal inflammatory factors. Results. The results demonstrated that the addition of IRW and IQW had a mitigating effect on DSS-induced intestinal inflammation. The level of Asp decreased in the serum of mice supplemented with IRW-DSS (P<0.05), and IQW enhanced the level of Leu, but lowered the level of Ser (P<0.05). IQW and IRW addition reduced the level of TNF-α and IL-17 (P<0.05). No other significant effects were observed. Conclusions. The present study demonstrated that intracolic administration of IRW and IQW might be a novel option for preventing inflammatory bowel disease via regulating the level of serum amino acid and enhancing the intestinal immune defense.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Article Subject
Colon
lcsh:Medicine
Colitis associated cancer
Inflammation
Inflammatory bowel disease
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
Basal (phylogenetics)
Mice
0302 clinical medicine
Internal medicine
Neoplasms
Gene expression
medicine
Animals
Humans
Colitis
Amino Acids
Dextran Sulfate Sodium
chemistry.chemical_classification
General Immunology and Microbiology
business.industry
Tumor Necrosis Factor-alpha
lcsh:R
Dextran Sulfate
Egg Proteins
Interleukin-17
General Medicine
medicine.disease
Inflammatory Bowel Diseases
digestive system diseases
Amino acid
Disease Models, Animal
030104 developmental biology
Endocrinology
chemistry
030220 oncology & carcinogenesis
Cytokines
medicine.symptom
business
Peptides
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 23146141 and 23146133
- Volume :
- 2019
- Database :
- OpenAIRE
- Journal :
- BioMed Research International
- Accession number :
- edsair.doi.dedup.....2c7cd4ea0cd26bca009cb5d636290eaf