Back to Search
Start Over
Opportunistic screening for osteoporosis using thoraco-abdomino-pelvic CT-scan assessing the vertebral density in rheumatoid arthritis patients
Opportunistic screening for osteoporosis using thoraco-abdomino-pelvic CT-scan assessing the vertebral density in rheumatoid arthritis patients
- Source :
- Osteoporosis International, Osteoporosis International, Springer Verlag, 2019, 30 (6), pp.1215-1222. ⟨10.1007/s00198-019-04931-w⟩
- Publication Year :
- 2018
-
Abstract
- Screening for osteoporosis is crucial in rheumatoid arthritis (RA) patients. The aim of this study was to assess the value of thoraco-abdomino-pelvic CT-derived bone mineral density (BMD) results in L1, compared to dual energy X-ray absorptiometry (DXA) results for osteoporosis screening in rheumatoid arthritis patients. Consecutive RA patients who underwent a CT-scan and DXA within a 2-year period were retrospectively included. The CT sagittal images were then evaluated for vertebral fractures from T4 to L5 using the Genant classification. The CT-attenuation values (in Hounsfield units (HU)) of trabecular bone in L1 were measured on axial images and compared to the DXA results. This study included 105 patients (mean age 61.1 years (± 9.5), 78.1% women). There were 28 patients (26.7%) with DXA-defined osteoporosis and 32 (30%) with osteoporotic fractures (vertebral and/or non-vertebral). The CT assessment indicated that the mean (SD) vertebral L1 attenuation was 142.2 HU (± 18.5). The diagnostic performance for the vertebral CT-attenuation measurement was acceptable: the AUC was 0.67 for predicting osteoporotic fractures and of 0.69 for predicting vertebral fractures. Among patients with osteoporotic fractures, there were 23 (74%) patients categorized as osteoporotic with a L1 CT-attenuation of 135 HU or less, whereas there were only 13 patients (42%) identified by DXA. CT offers a combined opportunistic screening for osteoporosis by assessing both vertebral fractures and bone density on routine CT-scans. This approach may be particularly interesting for RA patients with a high osteoporosis risk.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Bone density
Endocrinology, Diabetes and Metabolism
Osteoporosis
030209 endocrinology & metabolism
Arthritis, Rheumatoid
03 medical and health sciences
0302 clinical medicine
Absorptiometry, Photon
Bone Density
Internal medicine
Hounsfield scale
medicine
Humans
Mass Screening
ComputingMilieux_MISCELLANEOUS
Osteoporosis, Postmenopausal
Aged
Retrospective Studies
Bone mineral
Incidental Findings
Lumbar Vertebrae
business.industry
Middle Aged
medicine.disease
Sagittal plane
Rheumatology
medicine.anatomical_structure
Rheumatoid arthritis
Orthopedic surgery
Spinal Fractures
Female
030101 anatomy & morphology
Radiology
business
Tomography, X-Ray Computed
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Osteoporotic Fractures
Subjects
Details
- ISSN :
- 14332965 and 0937941X
- Volume :
- 30
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
- Accession number :
- edsair.doi.dedup.....2cab6d9dcad71bbe244f3e6f9b773af8
- Full Text :
- https://doi.org/10.1007/s00198-019-04931-w⟩