Back to Search
Start Over
Generation and Release of Mitochondrial-Derived Vesicles in Health, Aging and Disease
- Source :
- Journal of Clinical Medicine, Journal of Clinical Medicine, Vol 9, Iss 1440, p 1440 (2020)
- Publication Year :
- 2020
- Publisher :
- MDPI, 2020.
-
Abstract
- Mitochondria are intracellular organelles involved in a myriad of activities. To safeguard their vital functions, mitochondrial quality control (MQC) systems are in place to support organelle plasticity as well as physical and functional connections with other cellular compartments. In particular, mitochondrial interactions with the endosomal compartment support the shuttle of ions and metabolites across organelles, while those with lysosomes ensure the recycling of obsolete materials. The extrusion of mitochondrial components via the generation and release of mitochondrial-derived vesicles (MDVs) has recently been described. MDV trafficking is now included among MQC pathways, possibly operating via mitochondrial–lysosomal contacts. Since mitochondrial dysfunction is acknowledged as a hallmark of aging and a major pathogenic factor of multiple age-associated conditions, the analysis of MDVs and, more generally, of extracellular vesicles (EVs) is recognized as a valuable research tool. The dissection of EV trafficking may help unravel new pathophysiological pathways of aging and diseases as well as novel biomarkers to be used in research and clinical settings. Here, we discuss (1) MQC pathways with a focus on mitophagy and MDV generation; (2) changes of MQC pathways during aging and their contribution to inflamm-aging and progeroid conditions; and (3) the relevance of MQC failure to several disorders, including neurodegenerative conditions (i.e., Parkinson’s disease, Alzheimer’s disease) and cardiovascular disease.
- Subjects :
- mitochondrial-lysosomal axi
Endosome
mitochondrial damage
lcsh:Medicine
Disease
Review
exosomes
Mitochondrion
geroprotective interventions
03 medical and health sciences
0302 clinical medicine
mitochondrial-derived vesicles (MDVs)
mitochondrial-lysosomal axis
mitochondrial dynamic
Organelle
Mitophagy
exosome
Medicine
Cellular compartment
030304 developmental biology
0303 health sciences
business.industry
Neurodegeneration
lcsh:R
Settore MED/09 - MEDICINA INTERNA
neurodegeneration
biomarkers
General Medicine
medicine.disease
Microvesicles
mitochondrial dynamics
Cell biology
mitophagy
biomarker
geroprotective intervention
extracellular vesicle
business
extracellular vesicles
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Medicine, Journal of Clinical Medicine, Vol 9, Iss 1440, p 1440 (2020)
- Accession number :
- edsair.doi.dedup.....2cb13127924ef3676846575dbbc22db7