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Validation of the Framingham hypertension risk score in a middle eastern population
- Source :
- BMC Public Health, 21(1). BMC, BMC Public Health, Vol 21, Iss 1, Pp 1-8 (2021), BMC Public Health
- Publication Year :
- 2021
- Publisher :
- BMC, 2021.
-
Abstract
- Background The Framingham hypertension risk score is a well-known and simple model for predicting hypertension in adults. In the current study, we aimed to assess the predictive ability of this model in a Middle Eastern population. Methods We studied 5423 participants, aged 20–69 years, without hypertension, who participated in two consecutive examination cycles of the Tehran Lipid and Glucose Study (TLGS). We assessed discrimination based on Harrell’s concordance statistic (c-index) and calibration (graphical comparison of predicted vs. observed). We evaluated the original, recalibrated (for intercept and slope), and revised (for beta coefficients) models. Results Over the 3-year follow-up period, 319 participants developed hypertension. The Framingham hypertension risk score performed well in discriminating between individuals who developed hypertension and those who did not (c-index = 0.81, 95% CI: 0.79–0.83). Initially, there was a systematic underestimation of the original risk score (events predicted), which was readily corrected by a simple model revision. Conclusions The revised Framingham hypertension risk score can be used as a screening tool in public health and clinical practice to facilitate the targeting of preventive interventions in high-risk Middle Eastern people.
- Subjects :
- Adult
medicine.medical_specialty
genetic structures
Concordance
Population
030204 cardiovascular system & hematology
Iran
behavioral disciplines and activities
Risk Assessment
03 medical and health sciences
Young Adult
0302 clinical medicine
Risk Factors
Internal medicine
Epidemiology
medicine
Humans
030212 general & internal medicine
education
Statistic
Aged
education.field_of_study
Framingham Risk Score
Primary prevention
business.industry
Public health
Public Health, Environmental and Occupational Health
Middle Aged
Lipids
Risk prediction
Blood pressure
Glucose
nervous system
Hypertension
Risk score
Biostatistics
Public aspects of medicine
RA1-1270
business
psychological phenomena and processes
Research Article
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- BMC Public Health, 21(1). BMC, BMC Public Health, Vol 21, Iss 1, Pp 1-8 (2021), BMC Public Health
- Accession number :
- edsair.doi.dedup.....2cbcb03965707dac8394257b981332ec