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Profiling of Specific Gene Expression Pathways in Peripheral Cells from Prodromal Alzheimer's Disease Patients
- Source :
- Journal of Alzheimer's disease : JAD. 61(4)
- Publication Year :
- 2018
-
Abstract
- Herein, we performed a gene expression profiling in a cohort of 10 mild cognitive impairment (MCI), subdivided, according to the analysis of cerebrospinal fluid biomarkers, in prodromal Alzheimer's disease (AD) and non-AD MCI, as compared with 27 AD patients and 24 controls, in order to detect early gene expression alterations. We observed a significant upregulation of insulin (INS) and INS Receptor (INSR) expression levels in AD both prodromal and fully symptomatic, as compared with controls, but not in MCI subjects. Our results suggest an early dysregulation of INS and INSR in AD pathogenesis and pave the way to a possible utility of these transcripts as peripheral biomarkers.
- Subjects :
- 0301 basic medicine
Male
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Downregulation and upregulation
Alzheimer Disease
Antigens, CD
Gene expression
medicine
Humans
Insulin
Cognitive Dysfunction
Aged
biology
business.industry
General Neuroscience
Gene Expression Profiling
Case-control study
General Medicine
Middle Aged
medicine.disease
Receptor, Insulin
Gene expression profiling
Psychiatry and Mental health
Clinical Psychology
Insulin receptor
030104 developmental biology
Case-Control Studies
Immunology
biology.protein
Female
Geriatrics and Gerontology
Alzheimer's disease
business
030217 neurology & neurosurgery
Biomarkers
Frontotemporal dementia
Subjects
Details
- ISSN :
- 18758908
- Volume :
- 61
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of Alzheimer's disease : JAD
- Accession number :
- edsair.doi.dedup.....2ccac76beed95aaba74a3940dd7fa552