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Correlation between the Efficacy of Lamotrigine and the Serum Lamotrigine Level during the Remission Phase of Acute Bipolar II Depression: A Naturalistic and Unblinded Prospective Pilot Study
- Source :
- Biologicalpharmaceutical bulletin. 40(4)
- Publication Year :
- 2017
-
Abstract
- Lamotrigine has acute antidepressant effects in patients with bipolar disorder. However, there is little information regarding appropriate serum levels of lamotrigine and the time until remission after the start of lamotrigine therapy in patients with bipolar II depression. This was a naturalistic and unblinded prospective pilot study. Twelve patients' depressive symptoms were evaluated using the Montgomery-Asberg Depression Rating Scale (MADRS) at the start of treatment and at the time of remission, and blood samples were obtained at the time of remission. Mahalanobis distance was used to analyze the relationship between the MADRS improvement rate and the serum lamotrigine level. Furthermore, we calculated the Spearman's rank correlation coefficient for the relationship between the MADRS improvement rate and the serum lamotrigine level, and produced box plots of the serum lamotrigine level at remission and the time until remission. The Mahalanobis distance for the patient that was co-administered lamotrigine and valproic acid differed significantly from those of the other patients (p
- Subjects :
- Adult
Male
medicine.medical_specialty
Bipolar Disorder
Pharmaceutical Science
Pilot Projects
Lamotrigine
03 medical and health sciences
0302 clinical medicine
Rating scale
Internal medicine
medicine
Humans
Bipolar disorder
Prospective Studies
Depression (differential diagnoses)
Rank correlation
Aged
Pharmacology
Valproic Acid
business.industry
Triazines
Therapeutic effect
Remission Induction
General Medicine
Middle Aged
medicine.disease
Antidepressive Agents
030227 psychiatry
Treatment Outcome
Anesthesia
Antidepressant
Drug Therapy, Combination
Female
business
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 13475215
- Volume :
- 40
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Biologicalpharmaceutical bulletin
- Accession number :
- edsair.doi.dedup.....2cd280e3fa483404fb286bde0ec3a1f8