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Next Generation Sequencing-based Validation of the Revised International Staging System for Multiple Myeloma: An Analysis of the MMRF CoMMpass Study
- Source :
- Clinical Lymphoma Myeloma and Leukemia. 19:285-289
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Introduction The clinical application of the Revised International Staging System (R-ISS) for multiple myeloma may be limited by heterogeneity in clinical interphase fluorescent in situ hybridization (FISH) practices for detecting chromosomal abnormalities (CAs). Next generation sequencing (NGS)-based FISH (Seq-FISH) has demonstrated improved sensitivity and similar specificity relative to clinical FISH, and provides a standardized, single-pass method for identifying high-risk CAs. To date, calculating R-ISS stage using Seq-FISH (R-ISS-NGS) has not been validated. Patients and Methods We identified 672 patients with sufficient data to calculate R-ISS-NGS from the Multiple Myeloma Research Foundation (MMRF) CoMMpass Study. R-ISS-NGS was calculated from original ISS stage, lactate dehydrogenase, and CAs detected by Seq-FISH. Endpoints included overall survival and progression-free survival. We conducted multivariate analyses controlling for age and gender in order to compare outcomes across stages I to III of both the original ISS and R-ISS-NGS. Results The median follow-up was 24 months. The R-ISS-NGS resulted in significant redistribution of patients into stage II, relative to the original ISS. With respect to stage I, R-ISS-NGS stages II and III of were associated with worse progression-free survival or overall survival, more so than the staging schema of the ISS, thus validating the use of Seq-FISH in staging. Conclusion Using CAs detected by Seq-FISH and data from the CoMMpass study, we validated the R-ISS with a large, generalizable cohort. This study validates the substitution of Seq-FISH for clinical FISH, especially in large registry studies. Additionally, use of the validated R-ISS-NGS will strengthen outcomes research generated from the CoMMpass study.
- Subjects :
- Adult
Male
Oncology
Cancer Research
medicine.medical_specialty
Multivariate analysis
health care facilities, manpower, and services
Serum Albumin, Human
Stage ii
DNA sequencing
03 medical and health sciences
0302 clinical medicine
health services administration
Internal medicine
medicine
Humans
Longitudinal Studies
Prospective Studies
Stage (cooking)
Staging system
In Situ Hybridization, Fluorescence
Multiple myeloma
Aged
Neoplasm Staging
Retrospective Studies
Aged, 80 and over
Chromosome Aberrations
L-Lactate Dehydrogenase
business.industry
High-Throughput Nucleotide Sequencing
Hematology
Middle Aged
Prognosis
medicine.disease
Progression-Free Survival
030220 oncology & carcinogenesis
Cohort
Female
Outcomes research
Multiple Myeloma
beta 2-Microglobulin
business
human activities
Follow-Up Studies
030215 immunology
Subjects
Details
- ISSN :
- 21522650
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Clinical Lymphoma Myeloma and Leukemia
- Accession number :
- edsair.doi.dedup.....2ce546c128218157b1ccd326ef5fc8cf