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Enhancement of exon skipping in mdx52 mice by 2′-O-methyl-2-thioribothymidine incorporation into phosphorothioate oligonucleotides
- Source :
- Med. Chem. Commun.. 6:630-633
- Publication Year :
- 2014
-
Abstract
- Incorporation of 2′-O-methyl-2-thioribothymidine (s2Tm) into antisense oligoribonucleotides significantly enhanced the exon skipping activity in Duchenne muscular dystrophy model mice.
Details
- Language :
- English
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Med. Chem. Commun.
- Accession number :
- edsair.doi.dedup.....2cfe83afc06759685facafc3788e53b2