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Integrin subunit β1 and laminin γ1 chain expression: a potential prognostic biomarker in cervical cancer
- Source :
- Biomarkers in Medicine. 14:1461-1471
- Publication Year :
- 2020
- Publisher :
- Future Medicine Ltd, 2020.
-
Abstract
- Aim: The aim of this study was to analyze the prognostic value of integrin subunit β1 and laminin γ1 chain in patients with cervical cancer (CC). Materials & methods: The study included 96 samples. Cytological diagnosis, human papillomavirus (HPV) genotyping, HPV integration status and integrin subunit β1 and laminin γ1 chain expressions were performed or determined using Papanicolaou smear, INNO-LiPA® Genotyping Extra Kit, in situ hybridization, and immunocytochemistry, respectively. The association between variables was calculated using chi-squared and Fisher’s exact test; logistic regression analysis was performed to calculate odds ratios and CI at 95%. Results: Our results show that integrin subunit β1 and laminin γ1 chain expressions increase according to tumor progression. Integrin subunit β1 and laminin γ1 chain expressions are associated with cytological diagnosis (p
- Subjects :
- Adult
0301 basic medicine
Integrins
Protein subunit
Clinical Biochemistry
Immunocytochemistry
Integrin
Gene Expression
Uterine Cervical Neoplasms
In situ hybridization
Alphapapillomavirus
03 medical and health sciences
0302 clinical medicine
Laminin
Drug Discovery
Biomarkers, Tumor
Humans
Medicine
Mexico
Genotyping
In Situ Hybridization
biology
business.industry
Integrin beta1
Papillomavirus Infections
Biochemistry (medical)
Middle Aged
Prognosis
Immunohistochemistry
Molecular biology
Gene Expression Regulation, Neoplastic
Exact test
030104 developmental biology
Tumor progression
030220 oncology & carcinogenesis
biology.protein
Female
business
Subjects
Details
- ISSN :
- 17520371 and 17520363
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Biomarkers in Medicine
- Accession number :
- edsair.doi.dedup.....2d0213e772e680666de0765fb2721280
- Full Text :
- https://doi.org/10.2217/bmm-2020-0140