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Locomotion dependent neuron-glia interactions control neurogenesis and regeneration in the adult zebrafish spinal cord
- Source :
- Nature Communications, Nature Communications 12(1), 4857 (2021). doi:10.1038/s41467-021-25052-1, Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
- Publication Year :
- 2020
-
Abstract
- Physical exercise stimulates adult neurogenesis, yet the underlying mechanisms remain poorly understood. A fundamental component of the innate neuroregenerative capacity of zebrafish is the proliferative and neurogenic ability of the neural stem/progenitor cells. Here, we show that in the intact spinal cord, this plasticity response can be activated by physical exercise by demonstrating that the cholinergic neurotransmission from spinal locomotor neurons activates spinal neural stem/progenitor cells, leading to neurogenesis in the adult zebrafish. We also show that GABA acts in a non-synaptic fashion to maintain neural stem/progenitor cell quiescence in the spinal cord and that training-induced activation of neurogenesis requires a reduction of GABAA receptors. Furthermore, both pharmacological stimulation of cholinergic receptors, as well as interference with GABAergic signaling, promote functional recovery after spinal cord injury. Our findings provide a model for locomotor networks’ activity-dependent neurogenesis during homeostasis and regeneration in the adult zebrafish spinal cord.<br />The mechanisms stimulating adult neurogenesis are unclear. Here, the authors show the contribution of cholinergic and GABAergic signalling within the locomotor network to spinal cord neurogenesis during homeostasis and regeneration, showing neurogenesis depends on circuit activity in the adult zebrafish.
- Subjects :
- General Physics and Astronomy
metabolism [Neural Stem Cells]
Adult neurogenesis
Synaptic Transmission
Neural Stem Cells
Receptors, Cholinergic
cytology [Neural Stem Cells]
Spinal cord injury
Zebrafish
metabolism [Interneurons]
gamma-Aminobutyric Acid
Neurons
Spinal cord
Multidisciplinary
biology
Neurogenesis
growth & development [Spinal Cord]
medicine.anatomical_structure
metabolism [Neurons]
GABAergic
ddc:500
Neuroglia
Locomotion
Science
Neural circuits
General Biochemistry, Genetics and Molecular Biology
Article
Interneurons
Physical Conditioning, Animal
metabolism [Receptors, Cholinergic]
medicine
Animals
metabolism [Receptors, GABA-A]
metabolism [gamma-Aminobutyric Acid]
Progenitor cell
metabolism [Neuroglia]
cytology [Spinal Cord]
Regeneration (biology)
General Chemistry
Recovery of Function
medicine.disease
biology.organism_classification
Receptors, GABA-A
physiology [Spinal Cord]
Neuron
Neuroscience
Subjects
Details
- ISSN :
- 20411723
- Volume :
- 12
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Nature communications
- Accession number :
- edsair.doi.dedup.....2d2adfc366a4126b0db8b08ddae26f29