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Neurodevelopmental Defects: A Micropatterned Human‐Specific Neuroepithelial Tissue for Modeling Gene and Drug‐Induced Neurodevelopmental Defects (Adv. Sci. 5/2021)
- Source :
- Adv Sci (Weinh)
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- In article number 2001100, Yi‐Chin Toh and co‐workers combine hPSC micropatterning and a temporally‐sequenced induction protocol to specify neuroepithelial (NE) cells in spatial juxtaposition to mesoendoderm cells. This results in the formation of a reproducible and highly‐organized NE tissue. By evaluating NE tissue structural dysmorphia in the micropatterned NE model, gene‐ and drug‐induced neurodevelopmental defects can be successfully modelled. [Image: see text]
- Subjects :
- Back Cover
Drug
General Chemical Engineering
media_common.quotation_subject
General Engineering
Neuroepithelial Tissue
General Physics and Astronomy
Medicine (miscellaneous)
Biology
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Cell biology
General Materials Science
Human specific
Gene
media_common
Subjects
Details
- ISSN :
- 21983844
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Advanced Science
- Accession number :
- edsair.doi.dedup.....2d484dc7daa25ac4ef3919d70f7f9a9a