Managing complications of radiation therapy in head and neck cancer patients: Part V. Management of mucositis

Head and neck cancer is becoming a more recognizable pathology to the general population and dentists. The modes of treatment include surgery and/or radiation therapy. Where possible, pretreatment dental assessment shall be provided for these patients before they undergo radiation therapy. There are occasions, however, whereby head and neck cancer patients are not prepared optimally for radiation therapy. Because of this, they succumb to complicated oral adverse effects after radiation therapy. The second last part of this series reviews and discusses the management of complication that commonly occur to the oral mucosa, i.e. mucositis. © 2006 Elsevier. All rights reserved. This record was migrated from the OpenDepot repository service in June, 2017 before shutting down.
{"references":["Joyston-Bechal, S., Management of oral complications following radiotherapy (1992) Dent Update, 19, pp. 232-234,236-238; Blozis, G.G., Robinson, J.E., Oral tissue changes caused by radiation therapy and their management (1968) Dent Clin North Am, pp. 643-656. , Nov; Symonds RP Treatment-induced mucositis: an old problem with new remedies. Br J Cancer 1998;77:1689-95Mealey, B.L., Semba, S.E., Hallmon, W.W., The head and neck radiotherapy patient: Part 2 - Management of oral complications (1994) Compendium, 15, pp. 442-452,446. , 444; Hancock, P.J., Epstein, J.B., Sadler, G.R., Oral and dental management related to radiation therapy for head and neck cancer (2003) J Can Dent Assoc, 69, pp. 585-590; Carl, W., Local radiation and systemic chemotherapy: Preventing and managing the oral complications (1993) J Am Dent Assoc, 124, pp. 119-123; Makkonen, T.A., Bostrom, P., Vilja, P., Joensuu, H., Sucralfate mouth washing in the prevention of radiation-induced mucositis: A placebo-controlled double-blind randomized study (1994) Int J Radiat Oncol Biol Phys, 30, pp. 177-182; Allison, R.R., Vongtama, V., Vaughan, J., Shin, K.H., Symptomatic acute mucositis can be minimized or prophylaxed by the combination of sucralfate and fluconazole (1995) Cancer Invest, 13, pp. 16-22; Franzen, L., Henriksson, R., Littbrand, B., Zackrisson, B., Effects of sucralfate on mucositis during and following radiotherapy of malignancies in the head and neck region. A double-blind placebo-controlled study (1995) Acta Oncol, 34, pp. 219-223; Meredith, R., Salter, M., Kim, R., Spencer, S., Weppelmann, B., Rodu, B., Sucralfate for radiation mucositis: Results of a double-blind randomized trial (1997) Int J Radiat Oncol Biol Phys, 37, pp. 275-279; Carter, D.L., Hebert, M.E., Smink, K., Leopold, K.A., Clough, R.L., Brizel, D.M., Double blind randomized trial of sucralfate vs. placebo during radical radiotherapy for head and neck cancers (1999) Head Neck, 21, pp. 760-766; Epstein, J.B., Silverman Jr, S., Paggiarino, D.A., Crockett, S., Schubert, M.M., Senzer, N.N., Benzydamine HCL for prophylaxis of radiation-induced oral mucositis: Results form a multicenter, randomized, double-blind, placebo-controlled clinical trial (2001) Cancer, 92, pp. 875-885; Epstein, J.B., Truelove, E.L., Oien, I.I., Allison, C., Le, N.D., Epstein, M.S., Oral topical doxepin rinse: Analgesic effect in patients with oral mucosal pain due to cancer or cancer therapy (2001) Oral Oncol, 37, pp. 632-637; Chandu, A., Stulner, C., Bridgeman, A.M., Smith, A.C.H., Maintenance of mouth hygiene in patient with oral cancer in the immediate post-operative period (2002) Aust Dent J, 47, pp. 170-173; Foote, R.L., Loprinzi, C.L., Frank, A.R., O'Fallon, J.R., Gulavita, S., Tewfik, H.H., Randomized trial of a chlorhexidine mouthwash for alleviation of radiation-induced mucositis (1994) J Clin Oncol, 12, pp. 2630-2633; Nieuw Amerongen, A.V., Veerman, E.C., Current therapies for xerostomia and salivary gland hypofunction associated with cancer therapies (2003) Support Care Cancer, 11, pp. 226-231; Dodd, M.J., Miaskowdki, C., Dibble, S.L., Paul, S.M., MacPhail, L., Greenspan, D., Factors influencing oral mucositis in patients receiving chemotherapy (2000) Cancer Pract, 8, pp. 291-297; Larson, D.L., Management of complications of radiotherapy of the head and neck (1986) Surg Clin North Am, 66, pp. 169-182; Biron, P., Sebban, C., Gourmet, R., Chvetzoff, G., Philip, I., Blay, J.Y., Research controversies in management of oral mucositis (2000) Support Care Cancer, 8, pp. 68-71; Matejka, M., Nell, A., Kment, G., Schein, A., Leukauf, M., Porteder, H., Mailath, G., Sinzinger, H., Local benefit of prostaglandin E2 in radiochemotherapy-induced oral mucositis (1990) Br J Oral Maxillofac Surg, 28, pp. 89-91; Ritchie JR, Brown Jr, Guerra LR, Mason G. Dental care for the irradiated cancer patient. Quintessence Int 1985;16:837-42Epstein, J.B., Stevenson-Moore, P., Jackson, Mohamed, J.H., Spinelli, J.J., Prevention of oral mucositis in radiation therapy: A controlled study with benzydamine hydrochloride rinse (1989) Int J Radiat Oncol Biol Phys, 16, pp. 1571-1575; Pillsbury, H.C., Webster, W.P., Rosenman, J., Prostaglandin inhibitor and radiotherapy in advance head and neck cancers (1986) Arch Otolaryngol Head Neck Surg, 112, pp. 552-553; Meraw, S.J., Reeve, C.M., Dental considerations and treatment of the oncology patient receiving radiation therapy (1998) J Am Dent Assoc, 129, pp. 201-205"]}