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Higher circulating levels of IGF-1 are associated with longer leukocyte telomere length in healthy subjects
- Source :
- Barbieri, M, Paolisso, G, Kimura, M, Gardner, J P, Boccardi, V, Papa, M, von Bornemann Hjelmborg, J, Christensen, K, Brimacombe, M, Nawrot, T S, Staessen, J A, Pollak, M N & Aviv, A 2009, ' Higher circulating levels of IGF-1 are associated with longer leukocyte telomere length in healthy subjects ', Mechanisms of Ageing and Development, vol. 130, no. 11-12, pp. 771-6 . https://doi.org/10.1016/j.mad.2009.10.002
- Publication Year :
- 2009
-
Abstract
- Udgivelsesdato: nov-dec Mutations that inhibit the insulin-like growth factor-1 (IGF-1) extend the lifespan of worms, flies and mice. However, it appears that relatively low circulating levels of IGF-1 in humans are associated with aging-related diseases and diminished longevity. As leukocyte telomere length (LTL) is ostensibly a biomarker of human aging, we examined the relationship between LTL and blood IGF-1 in a healthy cohort. Our sample comprised 476 healthy, unrelated Caucasians (208 men and 268 women), aged 16-104 years, living in the West Coast of Southern Italy. We measured LTL by Southern blots and IGF-1 by enzyme-linked immunoassay. Both IGF-1 and LTL diminished with age (IGF-1, r=-0.601, P
- Subjects :
- Senescence
Adult
Male
medicine.medical_specialty
Aging
Adolescent
media_common.quotation_subject
Longevity
Biology
03 medical and health sciences
0302 clinical medicine
Insulin resistance
Sex Factors
Internal medicine
medicine
Leukocytes
Homeostasis
Humans
Insulin-Like Growth Factor I
030304 developmental biology
media_common
Aged
Aged, 80 and over
0303 health sciences
Healthy subjects
Middle Aged
Telomere
medicine.disease
Endocrinology
Ageing
Cohort
Biomarker (medicine)
Female
Insulin Resistance
030217 neurology & neurosurgery
Developmental Biology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Barbieri, M, Paolisso, G, Kimura, M, Gardner, J P, Boccardi, V, Papa, M, von Bornemann Hjelmborg, J, Christensen, K, Brimacombe, M, Nawrot, T S, Staessen, J A, Pollak, M N & Aviv, A 2009, ' Higher circulating levels of IGF-1 are associated with longer leukocyte telomere length in healthy subjects ', Mechanisms of Ageing and Development, vol. 130, no. 11-12, pp. 771-6 . https://doi.org/10.1016/j.mad.2009.10.002
- Accession number :
- edsair.doi.dedup.....2d7703b554e0d5963528124d55abe1ef
- Full Text :
- https://doi.org/10.1016/j.mad.2009.10.002